Chemical modification in the creation of novel biocatalysts

被引：98

作者：

Diaz-Rodriguez, Alba ^{[1
]}

Davis, Benjamin G. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2011年 / 15卷 / 02期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

ENANTIOSELECTIVE CATALYSIS; ARTIFICIAL METALLOENZYMES; DIRECTED EVOLUTION; AMINO-ACIDS; PROTEINS; ENZYME; CHEMISTRY; BIOCONJUGATION; IMMOBILIZATION; STABILIZATION;

D O I：

10.1016/j.cbpa.2010.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enzymes are able to perform a multitude of chemical and biochemical transformations with efficiencies that are typically unrivalled by chemical catalysts. However, these evolved systems may lack breadth or utility in other non-natural applications. Altering enzyme and protein scaffolds through covalent modification can expand the usefulness of native biocatalysts not only for synthetic application but also for therapeutic use. This review summarizes recent developments in the field of chemical modification of enzymes and how they can be applied to synthesis and biological research.

引用

页码：211 / 219

页数：9

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