Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies

被引：8

作者：

Collantoni, Enrico ^{[1
,2
]}

Solmi, Marco ^{[1
,2
]}

Gallicchio, Davide ^{[1
,2
]}

Santonastaso, Paolo ^{[1
,2
,3
]}

Meneguzzo, Paolo ^{[1
,2
]}

Carvalho, Andre F. ^{[4
]}

Stubbs, Brendon ^{[5
,6
,7
]}

Clementi, Maurizio ^{[8
]}

Pinato, Claudia ^{[8
]}

Forzan, Monica ^{[8
]}

Cassina, Matteo ^{[8
]}

Fontana, Francesca ^{[2
]}

Piva, Ivana ^{[2
]}

Siani, Roberta ^{[2
]}

Salvo, Pierandrea ^{[2
]}

Tenconi, Elena ^{[1
,2
,3
]}

Veronese, Nicola ^{[9
]}

Correll, Christoph U. ^{[10
,11
]}

Favaro, Angela ^{[1
,2
,3
]}

机构：

[1] Univ Padua, Dept Neurosci, Padua, Italy

[2] Biobank Veneto Reg Eating Disorders Units, BIO VEDA Grp, Biobanca Veneta & Disturbi Alimentaz, Veneto Region, Italy

[3] Univ Padua, CNC, Padua, Italy

[4] Univ Fed Ceara, Dept Clin Med, Translat Psychiat Res Grp, Fac Med, Fortaleza, Ceara, Brazil

[5] Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, London, England

[6] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England

[7] Anglia Ruskin Univ, Fac Hlth Social Care & Educ, Cambridge, England

[8] Univ Padua, Dept Woman & Child Hlth, Clin Genet Unit, Padua, Italy

[9] CNR, Ageing Sect, Rome, Italy

[10] Zucker Hillside Hosp, Dept Psychiat Res, Northwell Hlth, Glen Oaks, NY USA

[11] Hofstra Northwell Sch Med, Dept Psychiat & Mol Med Hempstead, Hempstead, NY USA

来源：

EUROPEAN EATING DISORDERS REVIEW | 2017年 / 25卷 / 06期

关键词：

polymorphism; anorexia nervosa; bulimia nervosa; catechol-O-methyltransferase (COMT); Val158Met; ANOREXIA-NERVOSA; FUNCTIONAL CONNECTIVITY; WORKING-MEMORY; DOPAMINE; ASSOCIATION; ABILITIES; GENOTYPE; RISK; BIAS;

D O I：

10.1002/erv.2555

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

ObjectivesWe investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). MethodsWe conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian Biobanca Veneta per i Disturbi Alimentari' biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. ResultsTen studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n=920, controls: n=261 controls) with 3541 ED patients (AN=2388; BN=233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I-2=0%] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I-2=0%) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I-2=0-44%). ConclusionsMeta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright (c) 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

引用

页码：524 / 532

页数：9

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