Rheumatoid arthritis association at 6q23

被引：316

作者：

Thomson, Wendy

Barton, Anne

Ke, Xiayi

Eyre, Steve

Hinks, Anne

Bowes, John

Donn, Rachelle

Symmons, Deborah

Hider, Samantha

Bruce, Ian N.

Wilson, Anthony G.

Marinou, Ioanna

Morgan, Ann

Emery, Paul

Carter, Angela

Steer, Sophia

Hocking, Lynne

Reid, David M.

Wordsworth, Paul

Harrison, Pille

Strachan, David

Worthington, Jane ^{[1
]}

机构：

[1] Univ Manchester, Arthritis Res Campaign Epidemiol Unit, Manchester M13 9PT, Lancs, England

[2] Univ Sheffield, Sch Med & Biomed Sci, Sheffield S10 2JF, S Yorkshire, England

[3] Chapel Allerton Hosp, Acad Unit Musculoskeletal Dis, Leeds LS7 4SA, W Yorkshire, England

[4] Univ Leeds, Inst Genet, Acad Unit Mol Vasc Med, Hlth & Therapeut Labs, Leeds LS2 9JT, W Yorkshire, England

[5] Kings Coll Hosp London, Natl Hlth Serv Fdn Trust, London SE5 9RS, England

[6] Univ Aberdeen, Dept Med & Therapeut, Bone Res Grp, Aberdeen AB25 2ZD, Scotland

[7] Univ Oxford, Botnar Res Ctr, Inst Musculoskeletal Sci, Oxford OX3 7LD, England

[8] St Georges Univ London, Div Community Hlth Sci, London SW17 0RE, England

来源：

NATURE GENETICS | 2007年 / 39卷 / 12期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/ng.2007.32

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5)-5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated ( trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 ( TNFAIP3).

引用

页码：1431 / 1433

页数：3

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