An efficient and rapid synthesis of 3-hydroxy-3-alkyl-2-oxindoles via Zn-mediated barbier-type reaction under aqueous conditions

被引：12

作者：

Chowhan, L. Raju ^{[1
]}

Reddy, Marri Sameer ^{[1
,2
]}

Kumar, Nandigama Satish ^{[1
]}

机构：

[1] Cent Univ Gujarat, Ctr Appl Chem, Gandhinagar 382030, Gujarat, India

[2] Cent Univ Gujarat, Sch Chem Sci, Gandhinagar 382030, Gujarat, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2017年 / 129卷 / 08期

关键词：

Allyl halides; barbier reaction; ecofriendly synthesis; isatin; oxindoles; green synthesis; water-mediated reaction; ENANTIOSELECTIVE SYNTHESIS; CELOSIA-ARGENTEA; PHYTOALEXINS; DERIVATIVES; INHIBITORS; MECHANISM; BRASSININ; SEEDS;

D O I：

10.1007/s12039-017-1329-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Arobust and rapid synthesis of 3-hydroxy-3-alkyl-2-oxindoles from isatins is described. This method introduces an ecofriendly, un-activated Zn dust, solid NH4Cl and substrates under aqueous conditions, which has produced the product in moderate to good yields. Without using column chromatography, majority of the compounds were isolated in analytically pure form. The progress of the reaction could be visualized by naked eye.

引用

页码：1205 / 1209

页数：5

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