Radical prostatectomy in high-risk and locally advanced prostate cancer: Mayo Clinic perspective

被引:28
作者
Stewart, Suzanne B. [1 ]
Boorjian, Stephen A. [1 ]
机构
[1] Mayo Clin, Dept Urol, Rochester, MN 55905 USA
关键词
Prostate cancer; Prostatectomy; High risk; Treatment; ANDROGEN-DEPRIVATION THERAPY; EXTERNAL-BEAM RADIOTHERAPY; QUALITY-OF-LIFE; RADIATION-THERAPY; CONSERVATIVE TREATMENT; ADJUVANT RADIOTHERAPY; PREDICTING SURVIVAL; MORTALITY OUTCOMES; PLUS ORCHIECTOMY; RANDOMIZED-TRIAL;
D O I
10.1016/j.urolonc.2014.10.003
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Men diagnosed with high-risk prostate cancer represent the cohort of prostate cancer patients at greatest risk for subsequent disease-specific mortality. Unfortunately, however, the classification of high-risk tumors remains imprecise and heterogeneous. There has been a historical reluctance to offer such patients aggressive local treatment, and considerable debate exists regarding the optimal management in this setting. Methods: We present here our institutional experience, as well as data from several other centers, with radical prostatectomy for high-risk tumors. Results: We discuss that surgery affords accurate pathological staging, thereby improving the identification of patients for secondary therapies. Moreover, prostatectomy not only provides durable local disease control but in addition numerous contemporary surgical series in high-risk patients have shown radical prostatectomy to be associated with excellent long-term cancer-specific survival. Further, although studies comparing surgical and radiotherapy modalities in high-risk prostate patients have been wrought with methodological challenges, consistently these observational studies have found equivalent to improved oncologic outcomes when surgery is utilized as the primary treatment. Conclusions: Herein, we review the advantages, long-term outcomes, and technique of surgery for high-risk prostate cancer. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:235 / 244
页数:10
相关论文
共 85 条
[81]   Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02 [J].
Wolmark, N ;
Wieand, HS ;
Hyams, DM ;
Colangelo, L ;
Dimitrov, NV ;
Romond, EH ;
Wexler, M ;
Prager, D ;
Cruz, AB ;
Gordon, PH ;
Petrelli, NJ ;
Deutsch, M ;
Mamounas, E ;
Wickerham, DL ;
Fisher, ER ;
Rockette, H ;
Fisher, B .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (05) :388-396
[82]   Secondary therapy, metastatic progression, and cancer-specific mortality in men with clinically high-risk prostate cancer treated with radical prostatectomy [J].
Yossepowitch, Ofer ;
Eggener, Scott E. ;
Serio, Angel M. ;
Caruer, Brett S. ;
Bianco, Fernando J., Jr. ;
Scardino, Peter T. ;
Eastham, James A. .
EUROPEAN UROLOGY, 2008, 53 (05) :950-959
[83]   Radical prostatectomy for clinically localized, high risk prostate cancer: Critical analysis of risk assessment methods [J].
Yossepowitch, Ofer ;
Eggener, Scott E. ;
Bianco, Fernando J., Jr. ;
Carver, Brett S. ;
Serio, Angel ;
Scardino, Peter T. ;
Eastham, James A. .
JOURNAL OF UROLOGY, 2007, 178 (02) :493-499
[84]   The Role of Robot-assisted Radical Prostatectomy and Pelvic Lymph Node Dissection in the Management of High-risk Prostate Cancer: A Systematic Review [J].
Yuh, Bertram ;
Artibani, Walter ;
Heidenreich, Axel ;
Kimm, Simon ;
Menon, Mani ;
Novara, Giacomo ;
Tewari, Ashutosh ;
Touijer, Karim ;
Wilson, Timothy ;
Zorn, Kevin C. ;
Eggener, Scott E. .
EUROPEAN UROLOGY, 2014, 65 (05) :918-927
[85]   Metastasis After Radical Prostatectomy or External Beam Radiotherapy for Patients With Clinically Localized Prostate Cancer: A Comparison of Clinical Cohorts Adjusted for Case Mix [J].
Zelefsky, Michael J. ;
Eastham, James A. ;
Cronin, Angel M. ;
Fuks, Zvi ;
Zhang, Zhigang ;
Yamada, Yoshiya ;
Vickers, Andrew ;
Scardino, Peter T. .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (09) :1508-1513