Down-Regulated Calcium-Sensing Receptor in Keratinocytes and Skin from Aged Mice and Humans Function

被引：4
作者：
Bollag, Wendy B. [1 ,2 ,3 ,4 ]
机构：
[1] Charlie Norwood VA Med Ctr, Augusta, GA USA
[2] Augusta Univ, Dept Physiol, Med Coll Georgia, 1120 15th St, Augusta, GA 30912 USA
[3] Augusta Univ, Dept Dermatol, Med Coll Georgia, Augusta, GA USA
[4] Augusta Univ, Dept Med, Med Coll Georgia, Augusta, GA USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2021年 / 141卷 / 11期
关键词：
EPIDERMAL DIFFERENTIATION;
D O I：
10.1016/j.jid.2021.04.005
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The calcium-sensing receptor (CaSR) is important in the skin, contributing to several epidermal functions, including differentiation, water permeability barrier repair, and wound healing. Celli et al. (2021) show that CaSR levels are reduced in keratinocytes/skin from aged individuals, with resulting impairment of key functions. CaSR agonists can correct these defects, suggesting a possible therapy to combat aging-related delayed skin wound healing.
引用
收藏
页码：2558 / 2561
页数：4
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