The regulatory roles of dietary fibers on host health via gut microbiota-derived short chain fatty acids

被引：47

作者：

Xu, Tong ^{[1
,4
]}

Wu, Xinyue ^{[1
,4
]}

Liu, Jia ^{[2
,4
]}

Sun, Jiayi ^{[3
]}

Wang, Xiaobo ^{[3
,4
]}

Fan, Gang ^{[2
,4
]}

Meng, Xianli ^{[3
]}

Zhang, Jing ^{[2
,4
]}

Zhang, Yi ^{[2
,4
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu, Peoples R China

[3] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China

[4] Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, Chengdu, Peoples R China

来源：

CURRENT OPINION IN PHARMACOLOGY | 2022年 / 62卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

CANCER;

D O I：

10.1016/j.coph.2021.11.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

As a component of nutraceuticals, dietary fibers (DFs) are essential for maintain human growth and health via the regulation of gut microbiota in the digestive tract. In this review, we summarize food-derived DFs and their effect on gut microbiota-derived short-chain fatty acids (SCFAs). DFs accelerate the production of SCFAs mainly by stimulating intestinal Lactobacillus, Bifidobacterium and Akkermansia to treat diabetes, obesity, cancer, inflammation and immunodeficiency. Further studies should focus on clarifying the detailed mechanism between DFs and diseases associated with gut microbiota-mediated SCFAs.

引用

页码：36 / 42

页数：7

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