A case with transient increases in serum S100A8/A9 levels implying acute inflammatory responses after pancreatic islet transplantation

被引：7

作者：

Ikemoto, Masaki ^{[1
]}

Matsumoto, Shinichi ^{[2
]}

Egawa, Hiroto ^{[2
]}

Okitsu, Teru ^{[2
]}

Iwanaga, Yasuhiro ^{[2
]}

Umemoto, Shinji ^{[2
]}

Itoh, Hiroshi ^{[1
]}

Murayama, Hiroshi ^{[3
]}

Fujita, Masatoshi ^{[1
]}

机构：

[1] Kyoto Univ, Fac Med, Sch Hlth Sci, Dept Lab Sci, Kyoto, Japan

[2] Kyoto Univ Hosp, Dept Transplantat Unit, Kyoto 6068507, Japan

[3] Yamasa Shoyu Co Ltd, Immunol Lab, Div Diagnost, Chiba 2880056, Japan

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 2007年 / 44卷

关键词：

D O I：

10.1258/000456307782268156

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We investigated a patient with type 1 diabetes mellitus undergoing pancreatic islets transplantation. In this patient, we evaluated the clinical usefulness of serial measurement of serum S100A8/A9 complex levels for detecting acute inflammatory responses associated with rejection of transplanted pancreatic islets. The serum S100A8/A9 complex was a more sensitive marker for acute inflammation associated with islet transplant rejection than the serum C-reactive protein. Thus, the serial measurement of the serum S100A8/A9 complex concentration is useful for monitoring the patients with pancreatic islet transplantation.

引用

页码：570 / 572

页数：3

共 5 条

[1] New ELISA system for myeloid-related protein complex (MRP8/14) and its clinical significance as a sensitive marker for inflammatory responses associated with transplant rejection [J].

Ikemoto, M ;

Tanaka, T ;

Takai, Y ;

Murayama, H ;

Tanaka, K ;

Fujita, M .

CLINICAL CHEMISTRY, 2003, 49 (04) :594-600

[2]

IKEMOTO M, 1993, CLIN CHEM, V39, P794

[3] Intrinsic function of S100A8/A9 complex as an anti-inflammatory protein in liver injury induced by lipopolysaccharide in rats [J].

Ikemoto, Masaki ;

Murayama, Hiroshi ;

Itoh, Hiroshi ;

Totani, Masayuki ;

Fujita, Masatoshi .

CLINICA CHIMICA ACTA, 2007, 376 (1-2) :197-204

[4] Efficacy of human islet isolation from the tail section of the pancreas for the possibility of living donor islet transplantation [J].

Matsumoto, S ;

Tanaka, K ;

Strong, DM ;

Reems, JA .

TRANSPLANTATION, 2004, 78 (06) :839-843

[5] Successful islet transplantation - Continued insulin reserve provides long-term glycemic control [J].

Ryan, EA ;

Lakey, JRT ;

Paty, BW ;

Imes, S ;

Korbutt, GS ;

Kneteman, NM ;

Bigam, D ;

Rajotte, RV ;

Shapiro, AMJ .

DIABETES, 2002, 51 (07) :2148-2157

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