Mild profile improvement of immune biomarkers in HIV/HCV-coinfected patients who removed hepatitis C after HCV treatment: A prospective study

被引：11

作者：

Garcia-Broncano, Pilar ^{[1
,2
]}

Maria Medrano, Luz ^{[1
]}

Berenguer, Juan ^{[3
,4
,5
]}

Brochado-Kith, Oscar ^{[1
]}

Gonzalez-Garcia, Juan ^{[6
]}

Jimenez-Sousa, Angeles ^{[1
]}

Quereda, Carmen ^{[7
]}

Sanz, Jose ^{[8
]}

Jesus Tellez, Maria ^{[9
]}

Diaz, Laura ^{[5
,10
]}

Luis JImenez, Jose ^{[5
,11
]}

Resino, Salvador ^{[1
]}

Carrero, A. ^{[4
]}

Miralles, P. ^{[4
]}

Lopez, J. C. ^{[4
]}

Parras, F. ^{[4
]}

Padilla, B. ^{[4
]}

Aldamiz-Echevarria, T. ^{[4
]}

Tejerina, F. ^{[4
]}

Diez, C. ^{[4
]}

Perez-Latorre, L. ^{[4
]}

Fanciulli, C. ^{[4
]}

Gutierrez, I ^{[4
]}

Ramirez, M. ^{[4
]}

Carretero, S. ^{[4
]}

Bellon, J. M. ^{[4
]}

Bermejo, J. ^{[4
]}

Berenguer, J. ^{[4
]}

Hontanon, V ^{[12
]}

Arribas, J. R. ^{[12
]}

Montes, M. L. ^{[12
]}

Bernardino, I ^{[12
]}

Pascual, J. F. ^{[12
]}

Zamora, F. ^{[12
]}

Pena, J. M. ^{[12
]}

Arnalich, F. ^{[12
]}

Diaz, M. ^{[12
]}

Gonzalez-Garcia, J. ^{[12
]}

Domingo, P. ^{[13
]}

Guardiola, J. M. ^{[13
]}

Van den Eynde, E. ^{[14
]}

Perez, M. ^{[14
]}

Ribera, E. ^{[14
]}

Crespo, M. ^{[14
]}

Casado, J. L. ^{[15
]}

Dronda, F. ^{[15
]}

Moreno, A. ^{[15
]}

Perez-Elias, M. J. ^{[15
]}

Sanfrutos, M. A. ^{[15
]}

Moreno, S. ^{[15
]}

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Infecc Viral & Inmunidad, Madrid, Spain

[2] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[3] Unidad Enfermedades Infecciosas VIH, Madrid, Spain

[4] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[5] IiSGM, Madrid, Spain

[6] Hosp Univ La Paz, Serv Med Interna, Unidad VIH, Madrid, Spain

[7] Hosp Univ Ramon y Cajal, Serv Enfermedades Infecciosas, Madrid, Spain

[8] Hosp Univ Principe Asturias, Serv Med Interna, Alcala De Henares, Spain

[9] Hosp Clin San Carlos, Serv Med Interna, Madrid, Spain

[10] Hosp Gen Univ Gregorio Maranon, Unidad Citometria Flujo & Sorter, Madrid, Spain

[11] Hosp Gen Univ Gregorio Maranon, Plataforma Lab, Madrid, Spain

[12] Hosp Univ La Paz, Madrid, Spain

[13] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[14] Hosp Univ Vall dHebron, Barcelona, Spain

[15] Hosp Univ Ramon y Cajal, Madrid, Spain

[16] Hosp Univ Principe Asturias, Alcala De Henares, Spain

[17] Hosp Univ La Princesa, Madrid, Spain

[18] Hosp Donostia, San Sebastian, Spain

[19] Hosp Clin San Carlos, Madrid, Spain

[20] Hosp Univ San Cecilio, Granada, Spain

[21] Hosp Clin Univ, Valencia, Spain

[22] Hosp Gen Univ, Valencia, Spain

[23] Hosp Univ La Fe, Valencia, Spain

[24] Hosp Univ Getafe, Getafe, Spain

[25] Fdn SEIMC GESIDA, Madrid, Spain

来源：

JOURNAL OF INFECTION | 2020年 / 80卷 / 01期

关键词：

Chronic hepatitis C; HIV; HCV therapy; Biomarkers; Inflammation; Immune activation; SUSTAINED VIROLOGICAL RESPONSE; ENDOTHELIAL DYSFUNCTION; NATURAL-HISTORY; VIRUS-INFECTION; CYTOKINE LEVELS; T-CELLS; LIVER; HIV; INFLAMMATION; PATHOGENESIS;

D O I：

10.1016/j.jinf.2019.09.020

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objective: There are a lack of consistency among articles in regards to the evolution of peripheral immune biomarkers after HCV therapy. We aimed to detect the most relevant changes in peripheral immune biomarkers among HIV/HCV-coinfected patients who achieved sustained virologic response (SVR) following peg-IFN-alpha/ribavirin therapy and to evaluate its normalization with respect to an HIV-monoinfected control group. Methods: We performed a prospective cohort study in 99 HIV/HCV-coinfected patients with samples at baseline (HIV/HCV-b-group) and at week 24 after SVR (HIV/HCV-f-group). We also used a control group of 39 HIV-monoinfected patients (HIV-group) negative for HCV and HBV infections, and who had undetectable HIV viral load and CD4(+) >500 cells/mm(3). Peripheral T cell subsets were assessed by flow cytometry and plasma biomarkers by immunoassays. Results: HIV/HCV-coinfected patients had higher values of in IL-10, IL-4, IP-10, IL-8, IL-1 beta, IL-18, IL-6, IFN-gamma, IL-12p70, TNF-alpha, sVCAM-1, sICAM-1, and sTNFR-1 than HIV control subjects, both at the beginning and at the end of follow-up. Moreover, three biomarkers (CD4(+)CD38(+), telomere length, and IL-1RA) were normalized in relation to the control group at the end of follow-up (the HIV/HCV-b group had higher values and the HIV/HCV-f group had similar values as the HIV-group). Additionally, LPS, IL-2, and IL-17A levels were higher in the HIV/HCV-f group than the HIV-group (24 weeks after SVR). During the follow-up, HIV/HCV-coinfected patients had a significant decrease by the end of follow-up in CD8(+)CD45RA(-)CD28(+), CD4(+)CD38(+), CD4(+)CD25(+)CD127(-/lo)(w), CD4(+)CD25(+)CD127(-/low) CD45RA(-), FABP2, LBP, IP-10, sVCAM1. Only CD4(+)CD38(+) was normalized. Conclusion: HIV/HCV-patients showed a slight improvement in the overall profile of immune biomarkers after achieving SVR. (C) 2019 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：99 / 110

页数：12

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