Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature)

被引:208
作者
Smolarz, Beata [1 ]
Szyllo, Krzysztof [2 ]
Romanowicz, Hanna [1 ]
机构
[1] Polish Mothers Mem Hosp, Res Inst, Dept Pathol, Lab Canc Genet, Rzgowska 281-289, PL-93338 Lodz, Poland
[2] Polish Mothers Mem Hosp, Res Inst, Dept Operat Gynaecol & Oncol Gynaecol, Rzgowska 281-289, PL-93338 Lodz, Poland
关键词
endometriosis; diagnostic; treatment; biomarkers; genes; GENOME-WIDE ASSOCIATION; DEEP INFILTRATING ENDOMETRIOSIS; QUALITY-OF-LIFE; ROBOTIC-ASSISTED LAPAROSCOPY; PELVIC PAIN; PERITONEAL-FLUID; MENSTRUAL DISSEMINATION; NEUROTROPHIC FACTOR; OXIDATIVE-STRESS; RISK-FACTORS;
D O I
10.3390/ijms221910554
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Endometriosis is a "mysterious " disease and its exact cause has not yet been established. Among the etiological factors, congenital, environmental, epigenetic, autoimmune and allergic factors are listed. It is believed that the primary mechanism of the formation of endometriosis foci is retrograde menstruation, i.e., the passage of menstrual blood through the fallopian tubes into the peritoneal cavity and implantation of exfoliated endometrial cells. However, since this mechanism is also observed in healthy women, other factors must also be involved in the formation of endometriosis foci. Endometriosis is in many women the cause of infertility, chronic pain and the deterioration of the quality of life. It also represents a significant financial burden on health systems. The article presents a review of the literature on endometriosis-a disease affecting women throughout the world.
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页数:29
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