Synthesis of [thiazolium-2,2′-14C2]-SAR97276A from [14C]-thiourea

被引：2

作者：

Herbert, John M. ^{[1
]}

Le Strat, Franck ^{[1
]}

Oumeddour, Delphine G. ^{[1
]}

Passey, Stephen C. ^{[1
]}

Taylor, Keith ^{[1
]}

Whitehead, David M. ^{[1
]}

机构：

[1] Sanofi Aventis, Dept Isotope Chem & Metabolite Synth, Alnwick Res Ctr, Alnwick NE66 2JH, Northd, England

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2011年 / 54卷 / 02期

关键词：

antimalarial; carbon-14; thiazole; C-14]-sulfurol; C-14]-thiourea;

D O I：

10.1002/jlcr.1816

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[thiazolium-2,2'-C-14(2)]-SAR97276A, a bis(thiazolium) antimalarial development candidate, was synthesized from [C-14]-thiourea with an overall radiochemical yield of 15%. The synthetic route involves a modified procedure for the synthesis of [C-14]-sulfurol, also a key intermediate in thiamine synthesis, which was developed due to unlabelled chemistry proving irreproducible with the radiolabelled substrate.

引用

页码：89 / 92

页数：4

共 3 条

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