Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson's Disease

被引：67

作者：

Ardashov, Oleg V. ^{[1
]}

Pavlova, Alla V. ^{[1
]}

Il'ina, Irina V. ^{[1
]}

Morozova, Ekaterina A. ^{[1
]}

Korchagina, Dina V. ^{[1
]}

Karpova, Elena V. ^{[1
]}

Volcho, Konstantin P. ^{[1
]}

Tolstikova, Tat'yana G. ^{[1
]}

Salakhutdinov, Nariman F. ^{[1
]}

机构：

[1] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 11期

关键词：

NEUROLEPTIC-INDUCED CATALEPSY; SECONDARY ALCOHOLS; MICE; OXIDATION; VERBENONE; RECEPTORS; EPOXIDE; KETONES; MPTP;

D O I：

10.1021/jm2001579

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possesses potent antiparkinsonian activity in both MPTP and haloperidol animal models. The use of compound 1 resulted in nearly full recovery of the locomotor and exploratory activities and was as effective as the comparator agent (levodopa). All eight stereoisomers of compound 1 have been synthesized and the influence of the absolute configuration on the antiparkinsonian activity of compound 1 was shown.

引用

页码：3866 / 3874

页数：9

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