Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson's Disease

被引：67
|
作者：
Ardashov, Oleg V. [1 ]
Pavlova, Alla V. [1 ]
Il'ina, Irina V. [1 ]
Morozova, Ekaterina A. [1 ]
Korchagina, Dina V. [1 ]
Karpova, Elena V. [1 ]
Volcho, Konstantin P. [1 ]
Tolstikova, Tat'yana G. [1 ]
Salakhutdinov, Nariman F. [1 ]
机构：
[1] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 11期
关键词：
NEUROLEPTIC-INDUCED CATALEPSY; SECONDARY ALCOHOLS; MICE; OXIDATION; VERBENONE; RECEPTORS; EPOXIDE; KETONES; MPTP;
D O I：
10.1021/jm2001579
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
(1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possesses potent antiparkinsonian activity in both MPTP and haloperidol animal models. The use of compound 1 resulted in nearly full recovery of the locomotor and exploratory activities and was as effective as the comparator agent (levodopa). All eight stereoisomers of compound 1 have been synthesized and the influence of the absolute configuration on the antiparkinsonian activity of compound 1 was shown.
引用
收藏
页码：3866 / 3874
页数：9
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