The Bidirectional Interactions Between Inflammation and Coagulation in Fracture Hematoma

被引：0
|
作者：
Ma, Yaping [1 ,2 ]
Zhou, Yinghong [3 ]
Wu, Fujun [1 ]
Ji, Wenjun [1 ]
Zhang, Jun [1 ]
Wang, Xin [1 ,2 ,3 ]
机构：
[1] Zunyi Med Univ, Affiliated Hosp, Dept Orthopaed Surg, Zunyi 563000, Peoples R China
[2] Zunyi Med Univ, Joint Orthopaed Res Ctr Zunyi Med Univ & Univ Roc, Zunyi, Peoples R China
[3] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia
来源：
TISSUE ENGINEERING PART B-REVIEWS | 2019年 / 25卷 / 01期
基金：
中国国家自然科学基金;
关键词：
fracture hematoma; inflammation; coagulation; fracture healing; ACTIVATED RECEPTOR (PAR)-1; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; TISSUE FACTOR; BLOOD-COAGULATION; FACTOR VIIA; ENDOTHELIAL-CELLS; CYTOKINE RESPONSE; CLOT PROPERTIES; BONE-FORMATION;
D O I：
10.1089/ten.teb.2018.0157
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Research regarding the intimate relationship between inflammation and coagulation in fracture hematoma has attracted increasing attention recently. However, the interaction of the two in the early fracture hematoma is not yet fully understood, especially the interplay between inflammatory and coagulation factor for hematoma structure. This review summarizes the interrelation between inflammation mediators and coagulation factors in the early fracture hematoma, and further delineates their influences on hematoma formation during fracture healing, thereby facilitating the advancement of knowledge of fracture hematoma and the development of new approaches to treat and manage bone fracture.
引用
收藏
页码：46 / 54
页数：9
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