Probing the Kinetics of Short-Distance Drug Release from Nanocarriers to Nanoacceptors

被引：40

作者：

Wang, Hong ^{[1
]}

Xu, Jun ^{[1
]}

Wang, Jinghao ^{[2
]}

Chen, Tao ^{[1
]}

Wang, Yong ^{[1
]}

Tan, Yan Wen ^{[1
]}

Su, Haibin ^{[2
]}

Chan, Khai Leok ^{[3
,4
]}

Chen, Hongyu ^{[1
]}

机构：

[1] Nanyang Technol Univ, Div Chem & Biol Chem, Singapore 637371, Singapore

[2] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore

[3] Inst Mat Res & Engn, Singapore 117602, Singapore

[4] ASTAR, Singapore 117602, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 45期

关键词：

drug delivery; kinetics; micelles; nanoparticles; diffusion model; GOLD-NANOPARTICLE DIMERS; BLOCK-COPOLYMER MICELLES; POLYMER MICELLES; DELIVERY SYSTEMS; MOLECULES; CANCER; ENCAPSULATION; PROBES;

D O I：

10.1002/anie.201001065

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quick release: Polymer-coated gold nanoparticles (AuNPs) are used as nanocarriers and nanoscale acceptors are used to represent proteins and lipid membranes in a model drug-delivery system. The fluorescence of a drug is quenched in the vicinity of the AuNPs but reemerges upon its release (see picture). The critical role of nanoacceptors in facilitating drug release is demonstrated. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8426 / 8430

页数：5

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