Unclassifiable, or simply unclassified interstitial lung disease?

被引：5

作者：

O'Callaghan, Marissa ^{[1
,2
]}

Bonella, Francesco ^{[3
]}

McCarthy, Cormac ^{[1
,2
]}

机构：

[1] St Vincents Univ Hosp, Dept Resp Med, Dublin 4, Ireland

[2] Univ Coll Dublin, Sch Med, Dublin 4, Ireland

[3] Ruhrlandklin Univ Hosp Essen, Dept Pneumol, Ctr Interstitial & Rare Lung Dis, Essen, Germany

来源：

CURRENT OPINION IN PULMONARY MEDICINE | 2021年 / 27卷 / 05期

关键词：

interstitial pneumonia with autoimmune features; progressive-fibrosing interstitial lung disease; unclassifiable interstitial lung disease; unclassified interstitial lung disease; IDIOPATHIC PULMONARY-FIBROSIS; MUC5B PROMOTER POLYMORPHISM; GENOME-WIDE ASSOCIATION; PNEUMONIA; SUSCEPTIBILITY; ABNORMALITIES; TELOMERASE; CLASSIFICATION; PIRFENIDONE; PREVALENCE;

D O I：

10.1097/MCP.0000000000000801

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Purpose of review Unclassifiable interstitial lung disease (ILD) comprises a subset of ILDs which cannot be classified according to the current diagnostic framework. This is a likely a heterogeneous group of diseases rather than a single entity and it is poorly defined and hence problematic for prognosis and therapy. Recent findings With increased treatment options for progressive fibrosing ILD it is increasingly relevant to correctly categorise ILD. This review article will summarise the definition and reasons for a diagnosis of unclassifiable ILD, the current management options and possible future approaches to improve diagnosis and differentiation within this broad subset. Finally, we will describe the implications of the labelling of unclassifiable ILD in clinical practice and research and whether the term 'unclassified' should be used, implying a less definitive diagnosis.

引用

页码：405 / 413

页数：9

共 85 条

[1] Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis [J].

Adams, Taylor S. ;

Schupp, Jonas C. ;

Poli, Sergio ;

Ayaub, Ehab A. ;

Neumark, Nir ;

Ahangari, Farida ;

Chu, Sarah G. ;

Raby, Benjamin A. ;

DeTullis, Giuseppe ;

Januszyk, Michael ;

Duan, Qiaonan ;

Arnett, Heather A. ;

Siddiqui, Asim ;

Washko, George R. ;

Homer, Robert ;

Yan, Xiting ;

Rosas, Ivan O. ;

Kaminski, Naftali .

SCIENCE ADVANCES, 2020, 6 (28)

[2] Computed Tomography Honeycombing Identifies a Progressive Fibrotic Phenotype with Increased Mortality across Diverse Interstitial Lung Diseases [J].

Adegunsoye, Ayodeji ;

Oldham, Justin M. ;

Bellam, Shashi K. ;

Montner, Steven ;

Churpek, Matthew M. ;

Noth, Imre ;

Vij, Rekha ;

Strek, Mary E. ;

Chung, Jonathan H. .

ANNALS OF THE AMERICAN THORACIC SOCIETY, 2019, 16 (05) :580-588

[3] Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis [J].

Allen, Richard J. ;

Guillen-Guio, Beatriz ;

Oldham, Justin M. ;

Ma, Shwu-Fan ;

Dressen, Amy ;

Paynton, Megan L. ;

Kraven, Luke M. ;

Obeidat, Ma'en ;

Li, Xuan ;

Ng, Michael ;

Braybrooke, Rebecca ;

Molina-Molina, Maria ;

Hobbs, Brian D. ;

Putman, Rachel K. ;

Sakornsakolpat, Phuwanat ;

Booth, Helen L. ;

Fahy, William A. ;

Hart, Simon P. ;

Hill, Mike R. ;

Hirani, Nik ;

Hubbard, Richard B. ;

McAnulty, Robin J. ;

Millar, Ann B. ;

Navaratnam, Vidyia ;

Oballa, Eunice ;

Parfrey, Helen ;

Saini, Gauri ;

Whyte, Moira K. B. ;

Zhang, Yingze ;

Kaminski, Naftali ;

Adegunsoye, Ayodeji ;

Strek, Mary E. ;

Neighbors, Margaret ;

Sheng, Xuting R. ;

Gudmundsson, Gunnar ;

Gudnason, Vilmundur ;

Hatabu, Hiroto ;

Lederer, David J. ;

Manichaikul, Ani ;

Newell, John D., Jr. ;

O'Connor, George T. ;

Ortega, Victor E. ;

Xu, Hanfei ;

Fingerlin, Tasha E. ;

Bosse, Yohan ;

Hao, Ke ;

Joubert, Philippe ;

Nickle, David C. ;

Sin, Don D. ;

Timens, Wim .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201 (05) :564-574

[4]

Allen RJ, 2017, LANCET RESP MED, V5, P869, DOI [10.1016/S2213-2600(17)30387-9, 10.1016/s2213-2600(17)30387-9]

[5] The telomere syndromes [J].

Armanios, Mary ;

Blackburn, Elizabeth H. .

NATURE REVIEWS GENETICS, 2012, 13 (10) :693-704

[6] Telomerase mutations in families with idiopathic pulmonary fibrosis [J].

Armanios, Mary Y. ;

Chen, Julian J. -L. ;

Cogan, Joy D. ;

Alder, Jonathan K. ;

Ingersoll, Roxann G. ;

Markin, Cheryl ;

Lawson, William E. ;

Xie, Mingyi ;

Vulto, Irma ;

Phillips, John A., III ;

Lansdorp, Peter M. ;

Greider, Carol W. ;

Loyd, James E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (13) :1317-1326

[7]

Biglia C, 2019, SARCOIDOSIS VASC DIF, V36, P108, DOI 10.36141/svdld.v36i2.8107

[8] The genetics of interstitial lung diseases [J].

Borie, Raphael ;

Le Guen, Pierre ;

Ghanem, Mada ;

Taille, Camille ;

Dupin, Clairelyne ;

Dieude, Philippe ;

Kannengiesser, Caroline ;

Crestani, Bruno .

EUROPEAN RESPIRATORY REVIEW, 2019, 28 (153)

[9] Unclassifiable Interstitial Lung Disease: Time to Shrink the Black Box [J].

Brown, A. Whitney .

ANNALS OF THE AMERICAN THORACIC SOCIETY, 2018, 15 (07) :806-807

[10] Treatment of progressive fibrosing interstitial lung diseases: a milestone in the management of interstitial lung diseases [J].

Cottin, Vincent .

EUROPEAN RESPIRATORY REVIEW, 2019, 28 (153)

← 1 2 3 4 5 6 7 8 9 →