Reversibly Light-Responsive Biodegradable Poly(carbonate) Micelles Constructed via CuAAC Reaction

被引：33

作者：

Hu, Ding ^{[1
]}

Peng, Hua ^{[1
]}

Niu, Yile ^{[1
]}

Li, Yefei ^{[1
]}

Xia, Yingchun ^{[1
]}

Li, Ling ^{[1
]}

He, Jingwen ^{[1
]}

Liu, Xiangyu ^{[1
]}

Xia, Xinnian ^{[1
]}

Lu, Yanbing ^{[1
]}

Xu, Weijian ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Inst Polymer Sci & Engn, Changsha 410082, Hunan, Peoples R China

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2015年 / 53卷 / 06期

关键词：

amphiphilic diblock copolymers; biodegradable; light-responsive micelles; polycarbonates; ring-opening polymerizations; self-assembly; spiropyran; stimuli-sensitive polymers; RING-OPENING POLYMERIZATION; HEPATOMA-TARGETING DELIVERY; BLOCK-COPOLYMER MICELLES; CLICK CHEMISTRY; SHAPED POLY(EPSILON-CAPROLACTONE); FUNCTIONALIZED POLYCARBONATES; ENERGY-TRANSFER; DRUG; NANOPARTICLES; PLATFORM;

D O I：

10.1002/pola.27499

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Light-responsive poly(carbonate)s PEG(113)-b-PMPCn-SP were synthesized via copper catalyzed azide-alkyne cycloaddition reaction between azide-modified spiropyran (SP-N-3) and amphiphilic copolymer PEG(113)-b-PMPCn. PEG(113)-b-PMPC25-SP can self-assemble to biocompatible micelles with an average diameter of similar to 96 nm and a critical aggregation concentration of 0.0148 mg mL(-1). Under 365 nm UV light irradiation, the characteristic absorption intensity of merocyanine (MC) progressively increased and most of the micellar aggregations were disrupted within 10 min, suggesting the completion of the transformation of hydrophobic SP to hydrophilic MC. Subsequent exposuring the micelles to 620 nm visible light, spherical micelles aggregated again. The light-controlled release and re-encapsulation behaviors of coumarin 102-loaded micelles were further investigated by fluorescence spectroscopy. This study provides a convenient way to construct smart poly(carbonate)s nanocarriers for controlled release and re-encapsulation of hydrophobic drugs. (C) 2014 Wiley Periodicals, Inc.

引用

页码：750 / 760

页数：11

共 60 条

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