Application of carbohydrates in approved small molecule drugs: A review

被引：42

作者：

Jiang, Hongfei ^{[1
,2
]}

Qin, Xiaofei ^{[3
]}

Wang, Qi ^{[4
]}

Xu, Qi ^{[5
]}

Wang, Jie ^{[2
]}

Wu, Yudong ^{[2
]}

Chen, Wujun ^{[2
]}

Wang, Chao ^{[2
]}

Zhang, Tingting ^{[2
]}

Xing, Dongming ^{[1
,2
,6
]}

Zhang, Renshuai ^{[1
,2
]}

机构：

[1] Qingdao Univ, Affiliated Hosp, Qingdao 266071, Peoples R China

[2] Qingdao Univ, Canc Inst, Qingdao 266071, Peoples R China

[3] Zunyi Med Univ, Dept Bioengn, Zhuhai Campus, Zhuhai 519041, Peoples R China

[4] Hainan Maternal & Childrens Med Ctr, Dept Crit Med, Haikou 570312, Hainan, Peoples R China

[5] Qilu Univ Technol, Shandong Acad Sci, Shandong Anal & Test Ctr, Lab Immunol Environm & Hlth, Jinan, Peoples R China

[6] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 223卷

基金：

中国国家自然科学基金;

关键词：

Carbohydrate; Novel drug development; Carbohydrate-containing drugs; Target; TOPOISOMERASE-II; STRUCTURAL BASIS; CRYSTAL-STRUCTURE; AMINOGLYCOSIDE ANTIBIOTICS; NUCLEOSIDE ANALOGS; SGLT2; INHIBITORS; BREAST-CANCER; BACTERIAL; BINDING; DISCOVERY;

D O I：

10.1016/j.ejmech.2021.113633

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Carbohydrates are an important energy source and play numerous key roles in all living organisms. Carbohydrates chemistry involved in diagnosis and treatment of diseases has been attracting increasing attention. Carbohydrates could be one of the major focuses of new drug discovery. Currently, however, carbohydrate-containing drugs account for only a small percentage of all drugs in clinical use, which does not match the important roles of carbohydrates in the organism. In other words, carbohydrates are a relatively untapped source of new drugs and therefore may offer exciting novel therapeutic opportunities. Here, we presented an overview of the application of carbohydrates in approved small molecule drugs and emphasized and evaluated the roles of carbohydrates in those drugs. The potential development direction of carbohydrate-containing drugs was presented after summarizing the advantages and challenges of carbohydrates in the development of new drugs. (C) 2021 Elsevier Masson SAS. All rights reserved.

引用

页数：22

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