BUB1 and BUBR1: multifaceted kinases of the cell cycle

被引：162

作者：

Bolanos-Garcia, Victor M. ^{[1
]}

Blundell, Tom L. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2011年 / 36卷 / 03期

基金：

英国惠康基金;

关键词：

SPINDLE ASSEMBLY CHECKPOINT; MOSAIC VARIEGATED ANEUPLOIDY; N-TERMINAL REGION; MITOTIC CHECKPOINT; CHROMOSOME-CONGRESSION; KINETOCHORE LOCALIZATION; MEDIATED INTERACTION; MUTATION ANALYSIS; CANCER-CELLS; LUNG-CANCER;

D O I：

10.1016/j.tibs.2010.08.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The multidomain protein kinases BUB1 and BUBR1 (Mad3 in yeast, worms and plants) are central components of the mitotic checkpoint for spindle assembly (SAC). This evolutionarily conserved and essential self-monitoring system of the eukaryotic cell cycle ensures the high fidelity of chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bi-oriented on the mitotic spindle. Despite their amino acid sequence conservation and similar domain organization, BUB1 and BUBR1 perform different functions in the SAC. Recent structural information provides crucial molecular insights into the regulation and recognition of BUB1 and BUBR1, and a solid foundation to dissect the roles of these proteins in the control of chromosome segregation in normal and oncogenic cells.

引用

页码：141 / 150

页数：10

共 78 条

[1] High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer [J].

Ando, Koji ;

Kakeji, Yosihiro ;

Kitao, Hiroyuki ;

Iimori, Makoto ;

Zhao, Yan ;

Yoshida, Rintaro ;

Oki, Eiji ;

Yoshinaga, Keiji ;

Matumoto, Takuya ;

Morita, Masaru ;

Sakaguchi, Yoshihisa ;

Maehara, Yoshihiko .

CANCER SCIENCE, 2010, 101 (03) :639-645

[2] Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis [J].

Bernard, P ;

Hardwick, K ;

Javerzat, JP .

JOURNAL OF CELL BIOLOGY, 1998, 143 (07) :1775-1787

[3] Mechanisms of aneuploidy in thyroid cancer cell lines and tissues:: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1 [J].

Bin, OY ;

Knauf, JA ;

Ain, K ;

Nacev, B ;

Fagin, JA .

CLINICAL ENDOCRINOLOGY, 2002, 56 (03) :341-350

[4] Assessment of the Mitotic Spindle Assembly Checkpoint (SAC) as the Target of Anticancer Therapies [J].

Bolanos-Garcia, Victor M. .

CURRENT CANCER DRUG TARGETS, 2009, 9 (02) :131-141

[5] The Crystal Structure of the N-Terminal Region of BUB1 Provides Insight into the Mechanism of BUB1 Recruitment to Kinetochores [J].

Bolanos-Garcia, Victor M. ;

Kiyomitsu, Tomomi ;

D'Arcy, Sheena ;

Chirgadze, Dimitri Y. ;

Grossmann, J. Guenter ;

Matak-Vinkovic, Dijana ;

Venkitaraman, Ashok R. ;

Yanagida, Mitsuhiro ;

Robinson, Carol V. ;

Blundell, Tom L. .

STRUCTURE, 2009, 17 (01) :105-116

[6] The conserved N-terminal region of the mitotic checkpoint protein BUBR1: A putative TPR motif of high surface activity [J].

Bolanos-Garcia, VM ;

Beaufils, S ;

Renault, A ;

Grossmann, JG ;

Brewerton, S ;

Lee, M ;

Venkitaraman, A ;

Blundell, TL .

BIOPHYSICAL JOURNAL, 2005, 89 (04) :2640-2649

[7] Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint [J].

Burton, Janet L. ;

Solomon, Mark J. .

GENES & DEVELOPMENT, 2007, 21 (06) :655-667

[8] Characterization of MAD2B and other mitotic spindle checkpoint genes [J].

Cahill, DP ;

da Costa, LT ;

Carson-Walter, EB ;

Kinzler, KW ;

Vogelstein, B ;

Lengauer, C .

GENOMICS, 1999, 58 (02) :181-187

[9] Mutations of mitotic checkpoint genes in human cancers [J].

Cahill, DP ;

Lengauer, C ;

Yu, J ;

Riggins, GJ ;

Willson, JKV ;

Markowitz, SD ;

Kinzler, KW ;

Vogelstein, B .

NATURE, 1998, 392 (6673) :300-303

[10] Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint [J].

Chen, RH .

EMBO JOURNAL, 2004, 23 (15) :3113-3121

← 1 2 3 4 5 6 7 8 →