Luminescent Gold Nanoparticles with Efficient Renal Clearance

被引：407
|
作者：
Zhou, Chen [1 ]
Long, Michael [2 ]
Qin, Yanping [1 ]
Sun, Xiankai [2 ]
Zheng, Jie [1 ]
机构：
[1] Univ Texas Dallas, Dept Chem, Richardson, TX 75080 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Radiol, Dallas, TX 75390 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 14期
关键词：
glutathione; gold; luminescence; nanoparticles; renal clearance; RAY COMPUTED-TOMOGRAPHY; QUANTUM DOTS; PARTICLE-SIZE; COLLOIDAL GOLD; CONTRAST AGENT; BIODISTRIBUTION; CANCER; MICE; STABILITY; CLUSTERS;
D O I：
10.1002/anie.201007321
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Going to waste: Renal clearance of 2-nm glutathione-coated luminescent gold nanoparticles (GS-AuNPs) was more than 10 to 100 times better than that of the similarly sized nonluminescent AuNPs coated by bis(p-sulfonatophenyl) phenylphosphine and cysteine. Urinary excretion of the particles was imaged with X-ray computed tomography (see picture of a mouse after injection of GS-AuNPs) and luminescence techniques in real time. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3168 / 3172
页数：5
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