Antibodies against cytokeratin 8/18 in a patient with de novo autoimmune hepatitis after living-donor liver transplantation

被引：34

作者：

Inui, A

Sogo, T

Komatsu, H

Miyakawa, H

Fujisawa, T

机构：

[1] Int Univ Hlth & Welf, Dept Pediat, Atami Hosp, Atami, Shizuoka, Japan

[2] Natl Def Med Coll, Dept Pediat, Tokorozawa, Saitama, Japan

[3] Teikyo Univ, Sch Med, Dept Internal Med 4, Teikyo, Japan

来源：

LIVER TRANSPLANTATION | 2005年 / 11卷 / 05期

关键词：

D O I：

10.1002/lt.20404

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Graft dysfunction mimicking autoimmune hepatitis rarely develops after liver transplantation for nonauto-immune disease. The mechanism(s) and causes of de novo autoimmune hepatitis are unknown. We examined autoantibodies serially in a patient with de novo autoimmune hepatitis and in patients without de novo autoimmune hepatitis after liver transplantation. Anticytokeratin 8/18 antibodies were detected in the first patient's sera after the onset of de novo autoimmune hepatitis, whereas other patients without de novo autoimmune hepatitis were seronegative throughout the follow-up period even with acute cellular rejection or other cause of liver dysfunction. In conclusion, the changes in cytokeratin 8/18 in hepatocytes might be one of the sources of pathogenesis of de novo autoimmune hepatitis after liver transplantation.

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页码：504 / 507

页数：4

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