The role of NFAT in the pathogenesis and targeted therapy of hematological malignancies

被引：8
作者：
Gao, Rili [1 ]
Zhang, Yikai [1 ,2 ]
Zeng, Chengwu [1 ]
Li, Yangqiu [1 ]
机构：
[1] Jinan Univ, Sch Med, Inst Hematol, Key Lab Regenerat Med,Minist Educ, Guangzhou 510632, Peoples R China
[2] Tianhe Nuoya Bioengn Co Ltd, Guangzhou 510663, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2022年 / 921卷
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Nuclear factor of activated T cells; Hematological malignancies; Target therapy; T cells immunity; T-CELL-ACTIVATION; MYELOID-LEUKEMIA AML; TRANSCRIPTION FACTOR; NUCLEAR FACTOR; LYMPHOCYTE-ACTIVATION; DOWN-REGULATION; CYCLOSPORINE-A; KAPPA-B; CALCINEURIN; EXPRESSION;
D O I：
10.1016/j.ejphar.2022.174889
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The nuclear factor of activated T cells (NFAT) family is well known for the survival of hemopoietic cells and plays an important role in the immune response. In recent decades, NFAT alteration was discovered in hematological malignancies, suggesting that targeted NFAT therapy may be a promising strategy for the treatment of hematological malignancies. In this review, we present an overview of the NFAT signaling pathway in lymphocytes as well as aberrant NFAT in hematological malignancies. Moreover, therapeutically targeting NFAT in hematological malignancies is also discussed in this review.
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页数：8
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