Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes

被引：84
作者：
Chomnawang, Mullika Traidej
Surassmo, Suvimol
Nukoolkarn, Veena S.
Gritsanapan, Wandee
机构：
[1] Mahidol Univ, Fac Pharm, Dept Microbiol, Bangkok 10400, Thailand
[2] Mahidol Univ, Fac Pharm, Dept Pharmacognosy, Bangkok 10700, Thailand
来源：
FITOTERAPIA | 2007年 / 78卷 / 06期
关键词：
Garcinia mangostana; acne; Propionibacterium acnes; anti-inflammation; reactive oxygen species; cytokines;
D O I：
10.1016/j.fitote.2007.02.019
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The present study was aimed to investigate the activity of Thai medicinal plants on inflammation caused by Propionibacterium acnes in terms of free radical scavenging and cytokine reducing properties. P. acnes have been recognized as pus-forming bacteria triggering an inflammation in acne. Antioxidant activity was determined by DPPH scavenging and NBT reduction assay. The result showed that Garcinia mangostana possessed the most significant antioxidant activity and reduced reactive oxygen species production. Houttuynia cordata, Eupatorium odoratum, and Senna alata had a moderate antioxidant effect. In addition, Garcinia mangostana extracts could reduce the TNF-alpha production as determined by ELISA. Garcinia mangostana was highly effective in scavenging free radicals and was able to suppress the production of pro-inflammatory cytokines. This study has identified the promising source of anti-inflammatory agent which could be useful in treatment of acne vulgaris. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：401 / 408
页数：8
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