pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates

被引：371

作者：

Felber, Arnaud E. ^{[1
]}

Dufresne, Marie-Helene ^{[1
]}

Leroux, Jean-Christophe ^{[1
]}

机构：

[1] ETH, Dept Chem & Appl Biosci, Inst Pharmaceut Sci, CH-8093 Zurich, Switzerland

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2012年 / 64卷 / 11期

关键词：

Vesicle; Polymeric micelle; Nanoparticle; Nanosphere; pH-sensitive; pH-responsive; Polyanion; Carboxylic acid; WATER-SOLUBLE DRUGS; N-ISOPROPYLACRYLAMIDE COPOLYMERS; RECEPTOR-MEDIATED ENDOCYTOSIS; STIMULI-RESPONSIVE VESICLES; IN-VITRO CHARACTERIZATION; ORAL DELIVERY; INTRACELLULAR DELIVERY; DIBLOCK COPOLYMERS; BLOCK-COPOLYMER; SUPRAMOLECULAR ASSEMBLIES;

D O I：

10.1016/j.addr.2011.09.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Titratable polyanions, and more particularly polymers bearing carboxylate groups, have been used in recent years to produce a variety of pH-sensitive colloids. These polymers undergo a coil-to-globule conformational change upon a variation in pH of the surrounding environment. This conformational change can be exploited to trigger the release of a drug from a drug delivery system in a pH-dependent fashion. This review describes the current status of pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates and their performance as nano-scale drug delivery systems, with emphasis on our recent contribution to this field. (c) 2011 Elsevier B.V. All rights reserved.

引用

页码：979 / 992

页数：14

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