An efficient synthesis of L-idose and L-iduronic acid thioglycosides and their use for the synthesis of heparin oligosaccharides

被引：47

作者：

Tatai, Janos ^{[1
]}

Osztrovszky, Gyoergyi ^{[1
]}

Kajtar-Peredy, Maria ^{[2
]}

Fugedi, Peter ^{[1
]}

机构：

[1] Hungarian Acad Sci, Dept Carbohydrate Chem, Chem Res Ctr, H-1025 Budapest, Hungary

[2] Hungarian Acad Sci, NMR Lab, Chem Res Ctr, H-1025 Budapest, Hungary

来源：

CARBOHYDRATE RESEARCH | 2008年 / 343卷 / 04期

关键词：

heparin; L-iduronic acid; thioglycosides; glycosylation; oligosaccharide synthesis;

D O I：

10.1016/j.carres.2007.12.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Efficient preparations of thioglycoside derivatives Of L-idose and L-iduronic acid are described. The method avoids the tedious chromatographic separations of furanose and pyranose anomeric mixtures, and affords the thioglycosides in a stereoselective manner. The L-idose and L-iduronic acid thioglycosides having combinations of different protecting groups proved to be efficient glycosyl donors in the synthesis of heparin disaccharides. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：596 / 606

页数：11

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