Diorganotin(IV) complexes of biologically potent 4(3H)-quinazolinone derived Schiff bases: Synthesis, spectroscopic characterization, DNA interaction studies and antimicrobial activity

被引：37

作者：

Prasad, Kollur Shiva ^{[1
]}

Kumar, Linganna Shiva ^{[1
]}

Chandan, Shivamallu ^{[2
]}

Jayalakshmi, Basvegowda ^{[3
]}

Revanasiddappa, Hosakere D. ^{[1
]}

机构：

[1] Univ Mysore, Dept Chem, Mysore 570006, Karnataka, India

[2] Univ Mysore, Dept Biotechnol, Mysore 570006, Karnataka, India

[3] Maharanis Sci Coll Women, Dept Bot, Mysore 570005, Karnataka, India

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2011年 / 81卷 / 01期

关键词：

3-Amino-2-methyl-4(3H)-quinazolinone; Spectral techniques; Thermal studies; DNA binding; Nuclease activity; ORGANOTIN COMPOUNDS; BINDING; LIGANDS; NI(II); CHEMISTRY; CD(II); MODE;

D O I：

10.1016/j.saa.2011.06.010

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Four Schiff base ligands and their corresponding organotin(IV) complexes have been synthesized and characterized by elemental analyses, IR, H-1 NMR, MS and thermal studies. The Schiff bases are obtained by the condensation of 3-amino-2-methyl-4(3H)-quinazolinone with different substituted aldehydes. The elemental analysis data suggest the stoichiometry to be 1:1 ratio formation. Infrared spectral data agreed with the coordination to the central metal ion through imine nitrogen, lactam oxygen and deprotonated phenolic oxygen atoms. All the synthesized compounds have been evaluated for antimicrobial activity against selected species of microorganisms. In addition, DNA binding/cleavage capacity of the compounds was analyzed by absorption spectroscopy, viscosity measurements and gel electrophoresis methods. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：276 / 282

页数：7

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