Structural features of mono- and tri-nuclear Zn(II) complexes with a non-steroidal anti-inflammatory drug as ligand

被引：64

作者：

Tarushi, Alketa ^{[1
]}

Totta, Xanthippi ^{[1
]}

Raptopoulou, Catherine P. ^{[2
]}

Psycharis, Vassilis ^{[2
]}

Psomas, George ^{[1
]}

Kessissoglou, Dimitris P. ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Fac Chem, Dept Gen & Inorgan Chem, GR-54124 Thessaloniki, Greece

[2] NCSR Demokritos, Inst Mat Sci, GR-15310 Aghia Paraskevi, Greece

来源：

DALTON TRANSACTIONS | 2012年 / 41卷 / 23期

关键词：

SUPEROXIDE-DISMUTASE ACTIVITY; N-PROPYL-NORFLOXACIN; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURES; BIOLOGICAL EVALUATION; MOLECULAR-STRUCTURE; ZINC(II) COMPLEXES; TOLFENAMIC ACID; COBALT(II) COMPLEXES; HERBICIDE COMPLEXES;

D O I：

10.1039/c2dt30547j

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The interaction of Zn(II) with the non-steroidal anti-inflammatory drug tolfenamic acid leads to the formation of the structurally characterized trinuclear [Zn-3(tolfenamato)(6)(CH3OH)(2)] complex. In the presence of the N, N'-donor heterocyclic ligands 1,10-phenanthroline and 2,2'-bipyridine at a range of ratios, the mononuclear Zn complexes of the general formulae [Zn(tolfenamato)(N, N'-donor) Cl] and [Zn(tolfenamato) 2(N, N'-donor)] have been isolated and structurally characterized by X-ray crystallography. The deprotonated tolfenamato ligands are coordinated to the Zn(II) ion through carboxylato oxygen atoms. Tolfenamic acid and its complexes exhibit good binding propensity to human or bovine serum albumin protein having relatively high binding constant values.

引用

页码：7082 / 7091

页数：10

共 75 条

[1] SYNTHESIS, STRUCTURE, AND SPECTROSCOPIC PROPERTIES OF COPPER(II) COMPOUNDS CONTAINING NITROGEN SULFUR DONOR LIGANDS - THE CRYSTAL AND MOLECULAR-STRUCTURE OF AQUA[1,7-BIS(N-METHYLBENZIMIDAZOL-2'-YL)-2,6-DITHIAHEPTANE]COPPER(II) PERCHLORATE [J].

ADDISON, AW ;

RAO, TN ;

REEDIJK, J ;

VANRIJN, J ;

VERSCHOOR, GC .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1984, (07) :1349-1356

[2]

[Anonymous], 2005, CRYSTALCLEAR

[3]

[Anonymous], 1997, SHELXL-97Programfor Crystal Structure Refinement

[4] Synthesis and X-ray diffraction study of Zn(II) complexes with o-phthalic acid and aromatic amines [J].

Baca, SG ;

Simonov, YA ;

Gerbeleu, NV ;

Gdaniec, M ;

Bourosh, PN ;

Timco, GA .

POLYHEDRON, 2001, 20 (9-10) :831-837

[5] Steric effects in controlling co-ordination environment in zinc 2-nitrobenzoate complexes [J].

Baruah, Abhilasha M. ;

Karmakar, Anirban ;

Baruah, Jubaraj B. .

INORGANICA CHIMICA ACTA, 2008, 361 (9-10) :2777-2784

[6] HALOCUPRATES(II) OF THE N-PHENYLPIPERAZINIUM MONOCATIONS AND DICATIONS - CRYSTAL AND MOLECULAR-STRUCTURE OF N-PHENYLPIPERAZINIUM TETRACHLOROCUPRATE(II) - CORRELATION OF THE ELECTRONIC-SPECTRUM VS DISTORTION OF THE CUCL42- ANIONS FROM TETRAHEDRAL SYMMETR [J].

BATTAGLIA, LP ;

CORRADI, AB ;

MARCOTRIGIANO, G ;

MENABUE, L ;

PELLACANI, GC .

INORGANIC CHEMISTRY, 1979, 18 (01) :148-152

[7] Formation of 3D networks by H-bonding from novel trinuclear or 1D chain complexes of zinc(II) and cadmium(II) with isonicotinic acid analogues and the effects of π-π stacking [J].

Bu, XH ;

Tong, ML ;

Li, JR ;

Chang, HC ;

Li, JL ;

Kitagawa, S .

CRYSTENGCOMM, 2005, 7 :411-416

[8] Superoxide dismutase activity of ternary copper complexes of sulfathiazole and imidazole derivatives.: Synthesis and properties of [CuL2(R-Him)2] [HL=4-amino-N-(thiazol-2-yl)benzenesulfonamide, R-Him=4-methylimidazole, 4,4-dimethylimidazoline or 1,2-dimethylimidazole].: Crystal structure of [CuL2(4,4-dimethylimidazoline)2] [J].

Casanova, J ;

Alzuet, G ;

Ferrer, S ;

Latorre, J ;

Ramírez, JA ;

Borrás, J .

INORGANICA CHIMICA ACTA, 2000, 304 (02) :170-177

[9] PREPARATION AND CRYSTAL-STRUCTURES OF BIS(O-PHENANTHROLINE)(ACETATO)ZINC(II) PERCHLORATE AND BIS(2,2'-BIPYRIDINE)(PYRIDINIOACETATO)ZINC(II) DIPERCHLORATE [J].

CHEN, XM ;

XU, ZT ;

YU, XL ;

MAK, TCW .

POLYHEDRON, 1994, 13 (13) :2079-2083

[10] Mononuclear metal complexes with Piroxicam:: Synthesis, structure and biological activity [J].

Christofis, P ;

Katsarou, M ;

Papakyriakou, A ;

Sanakis, Y ;

Katsaros, N ;

Psomas, G .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2005, 99 (11) :2197-2210

← 1 2 3 4 5 6 7 8 →