A systematic review of the association of diabetic retinopathy and cognitive impairment in people with Type 2 diabetes

被引：46

作者：

Crosby-Nwaobi, R. ^{[1
]}

Sivaprasad, S. ^{[2
]}

Forbes, A. ^{[1
]}

机构：

[1] Kings Coll London, Florence Nightingale Sch Nursing & Midwifery, London SE1 8WA, England

[2] Kings Coll Hosp London, Laser & Retinal Unit, London SE5 9RS, England

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2012年 / 96卷 / 02期

关键词：

Diabetes; Diabetic retinopathy; Cognitive impairment; Cognition; Dementia; RETINAL MICROVASCULAR ABNORMALITIES; RISK-FACTORS; ALZHEIMERS-DISEASE; OLDER-PEOPLE; LATE-LIFE; DEMENTIA; DECLINE; MELLITUS; POPULATION; DEPRESSION;

D O I：

10.1016/j.diabres.2011.11.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A systematic review of studies reporting data on the relationship between diabetic eye disease and cognitive impairment in Type 2 diabetes was conducted. The increase in cognitive impairment has mirrored the global increase in diabetes. The aim of the systematic review was to determine the level of association between diabetic retinopathy and cognitive impairment. Item selection, data extraction and critical appraisal were undertaken using standard procedures and independently verified by two researchers. 3 out of 10 potentially relevant studies were included. All studies showed a level of association between diabetic retinopathy and cognitive impairment, suggesting a near threefold increased risk of cognitive impairment in patients with diabetic retinopathy compared to those without. An association of cognitive impairment and severity of diabetic retinopathy was found in males. Diabetic retinopathy was more strongly linked to impairment in the cognitive domains of verbal learning and recent memory. An increased risk of cognitive impairment in patients with diabetic retinopathy was found in the reviewed studies. However, the relationship of severity of diabetic retinopathy and cognitive impairment has not been established. Further studies with standardized measurements for cognitive impairment and diabetic retinopathy are required to delineate this relationship and the role of other factors in this relationship. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：101 / 110

页数：10

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