Potential causes of cognitive alterations in temporal lobe epilepsy

被引：17
作者：
Chauviere, Laetitia [1 ]
机构：
[1] IPNP, INSERM U1266, 102 Rue Sante, F-75014 Paris, France
来源：
BEHAVIOURAL BRAIN RESEARCH | 2020年 / 378卷
关键词：
Cognition; Learning and memory; Neurological disease; Cognitive deficits; Excitatory-Inhibitory balance; HIPPOCAMPAL THETA SEQUENCES; EPILEPTIFORM EEG-DISCHARGES; LONG-TERM POTENTIATION; FUNCTIONAL CONNECTIVITY; MEMORY NETWORK; DENTATE GYRUS; PREFRONTAL CORTEX; INTERICTAL SPIKES; ILAE COMMISSION; SPATIAL MEMORY;
D O I：
10.1016/j.bbr.2019.112310
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Spatial and non-spatial memories are key processes whereby we process our environment on a daily basis, coding space, time and items to form unique memories. Both types of memory involve distributed and complex temporal lobe (TL) networks. In this review, we will discuss potential causes of spatial and non-spatial memory deficits, taking the example of temporal lobe epilepsy (TLE), a widespread neurological disorder characterized by cognitive comorbidities, in both animal models and TLE patients. We will start by briefly introducing TLE, then highlight by which underlying mechanisms TLE impairs TL-dependent cognitive functions.
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页数：8
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