Role of Uremic Toxins and Oxidative Stress in the Development of Chronic Kidney Disease-Mineral and Bone Disorder

被引：17

作者：

Tanaka, Hisae ^{[1
]}

Komaba, Hirotaka ^{[1
]}

Koizumi, Masahiro ^{[1
]}

Kakuta, Takatoshi ^{[1
]}

Fukagawa, Masafumi ^{[1
]}

机构：

[1] Tokai Univ, Sch Med, Div Nephrol Endocrinol & Metab, Isehara, Kanagawa 2591193, Japan

来源：

JOURNAL OF RENAL NUTRITION | 2012年 / 22卷 / 01期

关键词：

SKELETAL RESISTANCE; INDOXYL SULFATE; PARATHYROID-HORMONE; RAT MODEL; EXPRESSION;

D O I：

10.1053/j.jrn.2011.10.031

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The kidney plays an important role in the regulation of mineral metabolism. As kidney function declines, there is a progressive deterioration in mineral homeostasis, along with various abnormalities, including bone disease and vascular calcification, which has recently been named as "Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD).'' Although the precise mechanisms of this systemic disorder remain to be elucidated, accumulating evidence suggest that uremic toxins contribute substantially to the development of CKD-MBD, partly through evoking oxidative stress in the bone and cardiovascular systems. This brief review summarizes recent work on the role of uremic toxins and oxidative stress in the development of CKD-MBD. (C) 2012 by the National Kidney Foundation, Inc. All rights reserved.

引用

页码：98 / 101

页数：4

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