Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp.

被引：47

作者：

Orlandi Sardi, Janaina de Cassia ^{[1
,3
]}

Gullo, Fernanda Patricia ^{[1
]}

Freires, Irian Almeida ^{[3
]}

Pitangui, Nayla de Souza ^{[1
]}

Segalla, Maicon Petronio ^{[2
]}

Marisa Fusco-Almeida, Ana ^{[1
]}

Rosalen, Pedro Luiz ^{[3
]}

Regasini, Luis Octavio ^{[2
,4
]}

Soares Mendes-Giannini, Maria Jose ^{[1
]}

机构：

[1] UNESP Univ Estadual Paulista, Fac Pharmaceut Sci, Lab Clin Mycol, Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil

[2] UNESP Univ Estadual Paulista, Inst Chem, Dept Biochem & Chem Technol, BR-14800060 Araraquara, SP, Brazil

[3] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, BR-1341490 Piracicaba, SP, Brazil

[4] Inst Biosci Letters & Exact Sci, Dept Chem & Environm Sci, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2016年 / 86卷 / 04期

关键词：

Synergism; Candida albicans; Caffeic acid; Antifungal; SERIOUS FUNGAL-INFECTIONS; IN-VITRO EVALUATION; PHENETHYL ESTER; ALBICANS; PROPOLIS; PREVALENCE; RESISTANCE; VIRULENCE; STRAINS; EXTRACT;

D O I：

10.1016/j.diagmicrobio.2016.08.002

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We tested the antifungal potential of caffeic acid and 8 of its derivative esters against Candidaalbicans ATCC 90028 and 9 clinical isolatesand carried out a synergism assay with fluconazole and nystatin. Propyl caffeate (C3) showed the best antifungal activity against the tested strains. When in combination, C3 markedly reduced the MIC of fluconazole and nystatin with synergistic effect up to 64-fold. Finally, C3 showed a high IC50 value and selective indexagainst oral keratinocytes, demonstrating low toxicity against this cell type and selectivity for yeast cells. Further research should confirm its antifungal potential for development of combined therapy to treat C. albicans infections. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：387 / 391

页数：5

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