Matrine: A Promising Natural Product With Various Pharmacological Activities

被引：117
作者：
Zhang, Hong [1 ,2 ]
Chen, Linlin [1 ,2 ]
Sun, Xipeng [1 ]
Yang, Quanjun [1 ]
Wan, Lili [1 ]
Guo, Cheng [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Pharm, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷
基金：
中国国家自然科学基金;
关键词：
matrine; cancer; inflammation; apoptosis; autophagy; cell cycle; natural product; NF-KAPPA-B; LUNG-CANCER CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN OSTEOSARCOMA CELLS; STEM-LIKE CELLS; INHIBITS PROLIFERATION; INVASIVE PROPERTIES; SIGNALING PATHWAY; INDUCED AUTOPHAGY; PROSTATE-CANCER;
D O I：
10.3389/fphar.2020.00588
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens Aiton. At present, a large number of studies have proved that matrine has an anticancer effect can inhibit cancer cell proliferation, arrest cell cycle, induce apoptosis, and inhibit cancer cell metastasis. It also has the effect of reversing anticancer drug resistance and reducing the toxicity of anticancer drugs. In addition, studies have reported that matrine has a therapeutic effect on Alzheimer's syndrome, encephalomyelitis, asthma, myocardial ischemia, rheumatoid arthritis, osteoporosis, and the like, and its mechanism is mainly related to the inhibition of inflammatory response and apoptosis. Its treatable disease spectrum spans multiple systems such as the nervous system, circulatory system, and immune system. The antidisease effect and mechanism of matrine are diverse, so it has high research value. This review summarizes recent studies on the pharmacological mechanism of matrine, with a view to providing reference for subsequent research.
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页数：18
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