Subject-investigator reproducibility of the Unified Parkinson's Disease Rating Scale

被引：4

作者：

Seidel, Sydney E. ^{[2
]}

Tilley, Barbara C. ^{[3
]}

Huang, Peng ^{[4
]}

Palesch, Yuko Y. ^{[2
]}

Bergmann, Kenneth J. ^{[5
]}

Goetz, Christopher G. ^{[6
]}

Swearingen, Christopher J. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Dept Pediat, Biostat Program, Little Rock, AR 72202 USA

[2] Med Univ S Carolina, Div Biostat & Epidemiol, Charleston, SC 29425 USA

[3] Univ Texas Houston, Hlth Sci Ctr, Sch Publ Hlth, Houston, TX 77030 USA

[4] Johns Hopkins Univ, Oncol Biostat Div, Baltimore, MD 21205 USA

[5] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA

[6] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

来源：

PARKINSONISM & RELATED DISORDERS | 2012年 / 18卷 / 03期

关键词：

UPDRS; Parkinson's disease; Concordance correlation; Kappa; NET-PD; RELIABILITY; PATIENT; SECTION; DISABILITY; AGREEMENT; PHYSICIAN; NURSES;

D O I：

10.1016/j.parkreldis.2011.10.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To evaluate the subject-investigator agreement on the Unified Parkinson's Disease Rating Scale (UPDRS) subsections I and II. Methods: Subject-investigator agreement was estimated at baseline and endpoint by Kappa statistics for individual items and concordance correlations for subscale totals using data from two NIH Exploratory Trials in Parkinson's Disease studies. Results: All but two questions had moderate subject-investigator agreement at baseline and endpoint. Participants consistently rated their disease activity worse that investigators. Conclusion: UPDRS self-administration produces similar results to investigator-administration. Although slightly elevated, UPDRS self-administration can be accommodated in a clinical trial setting. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：230 / 233

页数：4

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