Regioselective protection of 10-deacetylbaccatin III and semi-synthesis of paclitaxel

被引：6

作者：

Hu, Zhang ^{[1
,2
]}

Ou, Li Li ^{[1
]}

Zhang, Guo Lin ^{[1
]}

Yu, Yong Ping ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Guangdong Ocean Univ, Coll Sci, Zhanjiang 524088, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2008年 / 19卷 / 02期

关键词：

paclitaxel; protecting group; 1,1'-thiocarbonyldiimidazole; regioselective; semi-synthesis;

D O I：

10.1016/j.cclet.2007.11.016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Semi-synthesis of paclitaxel was achieved in four steps from 10-deacetylbaccatin In (10-DAB III). The key steps are the regioselective protection at the hydroxyl group at C-7 of 1 O-DAB III, using 1, 1'-thiocarbonyldiiniidazole as a selective reagent, and the deprotection of the protected paclitaxel with a mixture of p-toluenesulfonic acid and 0.1 mol/L aqueous hydrochloride. (c) 2007 Yong Ping Yu. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：130 / 132

页数：3

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