Administration of β2-adrenergic agonists during the peri-implantation period does not improve implantation or pregnancy rates in intracytoplasmic sperm injection (ICSI) cycles

被引:18
作者
Pinheiro, OL
Cavagna, M
Baruffi, RLR
Mauri, AL
Petersen, C
Franco, JG
机构
[1] Univ Estadual Paulista, Fac Med Botucatu, Dept Obstet & Gynecol, Botucatu, SP, Brazil
[2] Fac Med Marilia, Dept Physiol Sci, Marilia, Brazil
[3] Sinha Junqueira Matern Fdn, Ctr Human Reprod, Ribeirao Preto, Brazil
[4] Univ Santo Amaro, Postgrad Program Maternal Fetal Hlth, Sao Paulo, Brazil
[5] Univ Ribeirao Preto, UNAERP, Dept Obstet Gynecol, Ribeirao Preto, Brazil
关键词
ICSI; implantation rates; ritodrine; terbutaline; uterine contractility; UTERINE CONTRACTILITY; EMBRYO-TRANSFER; FERTILIZATION; TIME; RECEPTIVITY;
D O I
10.1023/B:JARG.0000013652.17193.38
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Purpose: The objective of the present investigation was to determine implantation and pregnancy rates in patients undergoing ICSI and treated with beta(2)-adrenergic agonists, considering the uterine-relaxing action of these agents. Methods: A total of 225 women undergoing ICSI at the Center for Human Reproduction, "Sinha Junqueira" Maternity Foundation, entered the study. Patient participation in each group was random, by drawing lots, using a randomization table previously elaborated for the study (2:2:1). The group I (90 women) received 10 mg of terbutaline daily for 15 days starting on the day of oocyte retrieval; group II (90 women) received 20 mg of ritodrine daily during the same period of time as group I; group III (45 patients) received no treatment and was used as control. The evaluation was interrupted in 3 patients of group I and in 30 patients of group II because of a high incidence of side effects. Results: Pregnancy, implantation, and miscarriage rates were not significantly different (p>0.05) between the three groups: 29.88%, 13.25%, and 26.9% for group I; 33.33%, 17.5%, and 10.0% for group II; 28.88%, 15.07%, and 15.38% for group III, respectively. Conclusions: The results of this study do not support the routine use of beta(2)-adrenergic agonists during the peri-implantation period in assisted reproductive technology cycles.
引用
收藏
页码:513 / 516
页数:4
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