Nucleotide excision repair protein ERCC1 and tumour-infiltrating lymphocytes are potential biomarkers of neoadjuvant platinum resistance in high grade serous ovarian cancer

被引:12
作者
Scurry, James [1 ,2 ,3 ]
van Zyl, Belinda [2 ,3 ]
Gulliver, Damien [2 ,3 ]
Otton, Geoffrey [4 ]
Jaaback, Kenneth [4 ]
Lombard, Janine [5 ]
Vilain, Ricardo E. [1 ,2 ,3 ]
Bowden, Nikola A. [2 ,3 ]
机构
[1] Pathol NSW, New Lambton Hts, NSW, Australia
[2] Univ Newcastle, Hunter Med Res Inst, Callaghan, NSW, Australia
[3] Univ Newcastle, Sch Med & Publ Hlth, Fac Hlth, Callaghan, NSW, Australia
[4] John Hunter Hosp, Dept Gynaecol Oncol, Hunter New England Area Hlth Serv, New Lambton Hts, NSW, Australia
[5] Calvary Mater Hosp, Dept Med Oncol, Waratah, NSW, Australia
基金
英国医学研究理事会;
关键词
Ovarian cancer; ERCC1; Tumour-infiltrating lymphocytes; Neoadjuvant chemotherapy; Resistance; CHEMOTHERAPY; CELLS; EXPRESSION; SENSITIVITY; PREDICTION; CISPLATIN; SURVIVAL; RNA;
D O I
10.1016/j.ygyno.2018.08.030
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective. ERCC1 is a nucleotide excision repair protein that may have a role in drug resistance in high grade serous ovarian cancer (HGSOC). We hypothesized that ERCC1 expression and tumour infiltrating lymphocytes (TILS) are induced by chemotherapy in HGSOC, which may be prognostically useful. Methods. 115 HGSOC patients were used for this study. 92 (80%) of the tissue analysed had not been exposed to platinum chemotherapy. The remaining 20% (n = 23) of cases received combination or monotherapy with carboplatin before tissue was collected. Immunohistochemistry was used to score for ERCC1 expression and morphology to score for TILs. Correlation analysis of all clinical parameters, TILs and ERCC1 and Kaplan-Meier survival analysis was performed using the ERCC1 and TILs scoring parameters (0, 1, 2 or 3). Results. ERCC1 expression was 2-fold higher in the neoadjuvant chemotherapy group compared to the primary cytoreductive surgery group (p < 0.0001). The mean overall survival for the neoadjuvant group with high ERCC1 was 141.6 +/- 20.2 months which was significantly longer than absent ERCC1 survival of 61 + 22.6 months (p = 0.028). ERCC1 score strongly correlated with TILs score across the whole cohort (0.349, p = 1.3 x 10(-4)) suggesting there is a relationship between ERCC1 expression and TILs, but this requires further investigation. Conclusion. In conclusion, ERCC1 was identified as a potential biomarker of platinum response overall survival in HGSOC undergoing neoadjuvant HGSOC treatment. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:306 / 310
页数:5
相关论文
共 24 条
[1]   Overexpression of DDB2 enhances the sensitivity of human ovarian cancer cells to cisplatin by augmenting cellular apoptosis [J].
Barakat, Bassant M. ;
Wang, Qi-En ;
Han, Chunhua ;
Milum, Keisha ;
Yin, De-Tao ;
Zhao, Qun ;
Wani, Gulzar ;
Arafa, El-Shaimaa A. ;
El-Mahdy, Mohamed A. ;
Wani, Altaf A. .
INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (04) :977-988
[2]   Nucleotide excision repair: Why is it not used to predict response to platinum-based chemotherapy? [J].
Bowden, Nikola A. .
CANCER LETTERS, 2014, 346 (02) :163-171
[3]   Small interfering RNA-induced suppression of ERM enhances sensitivity of human cancer cells to cisplatin [J].
Chang, IY ;
Kim, MH ;
Kim, HB ;
Lee, DY ;
Kim, SH ;
Kim, HY ;
You, HJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 327 (01) :225-233
[4]   ERCC1-expressing circulating tumor cells as a potential diagnostic tool for monitoring response to platinum-based chemotherapy and for predicting post-therapeutic outcome of ovarian cancer [J].
Chebouti, Issam ;
Kuhlmann, Jan Dominik ;
Buderath, Paul ;
Weber, Stephan ;
Wimberger, Pauline ;
Bokeloh, Yvonne ;
Hauch, Siegfried ;
Kimmig, Rainer ;
Kasimir-Bauer, Sabine .
ONCOTARGET, 2017, 8 (15) :24303-24313
[5]   ERCC1 AND ERCC2 EXPRESSION IN MALIGNANT-TISSUES FROM OVARIAN-CANCER PATIENTS [J].
DABHOLKAR, M ;
BOSTICKBRUTON, F ;
WEBER, C ;
BOHR, VA ;
EGWUAGU, C ;
REED, E .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (19) :1512-1517
[6]   Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum [J].
DeLoia, Julie A. ;
Bhagwat, Nikhil R. ;
Darcy, Kathleen M. ;
Strange, Mary ;
Tian, Chunquio ;
Nuttall, Kevin ;
Krivak, Thomas C. ;
Niedernhofer, Laura J. .
GYNECOLOGIC ONCOLOGY, 2012, 126 (03) :448-454
[7]   High ERCC1 expression is associated with platinum-resistance, but not survival in patients with epithelial ovarian cancer [J].
Du, Pei ;
Wang, Yifeng ;
Chen, Liquan ;
Gan, Yaping ;
Wu, Qinian .
ONCOLOGY LETTERS, 2016, 12 (02) :857-862
[8]   Increased nucleotide excision repair in cisplatin-resistant ovarian cancer cells - Role of ERCC1-XPF [J].
Ferry, KV ;
Hamilton, TC ;
Johnson, SW .
BIOCHEMICAL PHARMACOLOGY, 2000, 60 (09) :1305-1313
[9]   Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer [J].
Goode, Ellen L. ;
Block, Matthew S. ;
Kalli, Kimberly R. ;
Vierkant, Robert A. ;
Chen, Wenqian ;
Fogarty, Zachary C. ;
Gentry-Maharaj, Aleksandra ;
Toloczko, Aleksandra ;
Hein, Alexander ;
Bouligny, Aliecia L. ;
Jensen, Allan ;
Osorio, Ana ;
Hartkopf, Andreas D. ;
Ryan, Andy ;
Chudecka-Glaz, Anita ;
Magliocco, Anthony M. ;
Hartmann, Arndt ;
Jung, Audrey Y. ;
Gao, Bo ;
Hernandez, Brenda Y. ;
Fridley, Brooke L. ;
McCauley, Bryan M. ;
Kennedy, Catherine J. ;
Wang, Chen ;
Karpinskyj, Chloe ;
de Sousa, Christiani B. ;
Tiezzi, Daniel G. ;
Wachter, David L. ;
Herpel, Esther ;
Taran, Florin Andrei ;
Modugno, Francesmary ;
Nelson, Gregg ;
Lubinski, Jan ;
Menkiszak, Janusz ;
Alsop, Jennifer ;
Lester, Jenny ;
Garcia-Donas, Jesus ;
Nation, Jill ;
Hung, Jillian ;
Palacios, Jose ;
Rothstein, Joseph H. ;
Kelley, Joseph L. ;
de Andrade, Jurandyr M. ;
Robles-Diaz, Luis ;
Intermaggio, Maria P. ;
Widschwendter, Martin ;
Beckmann, Matthias W. ;
Ruebner, Matthias ;
Jimenez-Linan, Mercedes ;
Singh, Naveena .
JAMA ONCOLOGY, 2017, 3 (12)
[10]   Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease [J].
Gregg, Siobhan Q. ;
Robinson, Andria Rasile ;
Niedernhofer, Laura J. .
DNA REPAIR, 2011, 10 (07) :781-791