A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatinand its 2-epi and 2,4-diepi analogues

被引：17

作者：

Nieto-Garcia, Olaia ^{[1
]}

Lago-Santome, Hugo ^{[1
]}

Cagide-Fagin, Fernando

Ortiz-Lara, Juan Carlos

Alonso, Ricardo ^{[1
]}

机构：

[1] Univ Santiago, Dept Quim Organ, Santiago De Compostela 15782, Spain

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 04期

关键词：

SODIUM TRIACETOXYBOROHYDRIDE; AMARYLLIDACEAE CONSTITUENTS; BIOLOGICAL EVALUATION; ALKALOIDS; REDUCTION; 7-DEOXYPANCRATISTATIN; NARCICLASINE; GENERATION; KETONES;

D O I：

10.1039/c1ob06374j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A full account is given for the total synthesis and the cytotoxic activity against the human lung tumoral cell line NCI-H460 of (+/-)-7-deoxy-pancratistatin and its 2-epi- and 2,4-diepi- unnatural analogues.

引用

页码：825 / 834

页数：10

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