Palladium-catalyzed cycloisomerisation reaction of 1,6-enyne acetic esters to form five-embered nitrogenated heterocyclic conjugated trienes

被引：5
作者：
He, Ting [1 ]
Gao, Pin [2 ,3 ]
Fang, Shan [1 ]
Chi, Yaling [1 ]
Chen, Yuantao [1 ]
机构：
[1] Qinghai Normal Univ, Sch Chem & Chem Engn, Xining 810008, Qinghai, Peoples R China
[2] Xi An Jiao Tong Univ, Sch Sci, Dept Chem, Xian 710049, Shaanxi, Peoples R China
[3] Xi An Jiao Tong Univ, MOE Key Lab Nonequilibrium Synth & Modulat Conden, Xian 710049, Shaanxi, Peoples R China
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 52期
基金：
中国国家自然科学基金;
关键词：
Cycloisomerisation; 1,6-Enynes; Palladium-catalyzed; Nitrogenated heterocyclic; Conjugated trienes; OXIDATIVE CYCLIZATION; (-)-KAINIC ACID; DOMOIC ACID; ENYNES; CONSTRUCTION; (+)-CONESSINE; BENZOFURANS; ACTIVATION; CHLORIDE;
D O I：
10.1016/j.tetlet.2017.11.018
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed cycloisomerisation reaction of 1,6-enyne acetic esters have been developed. This cyclization reaction shows excellent regioselectivity and good functional group tolerance to obtain five-membered nitrogenated heterocyclic conjugated trienes in moderate to excellent yields. The resulting conjugated trienes could be facilely converted to highly substituted benzenes through Diels-Alder reactions. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4832 / 4835
页数：4
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