Risk of osteoporotic fracture and hip fracture in patients with chronic obstructive pulmonary disease

被引：5

作者：

Diez-Manglano, J. ^{[1
]}

Lopez-Garcia, F. ^{[2
]}

Barquero-Romero, J. ^{[3
]}

Galofre-Alvaro, N. ^{[4
]}

Montero-Rivas, L. ^{[5
]}

Almagro-Mena, P. ^{[6
]}

Soriano, J. B. ^{[7
]}

机构：

[1] Hosp Royo Villanovo, Zaragoza, Spain

[2] Hosp Vega Baja, Alicante, Spain

[3] Complejo Univ Infanta Cristina, Badajoz, Spain

[4] Hosp Badalona, Barcelona, Spain

[5] Hosp Comarcal Axarquia, Malaga, Spain

[6] Hosp Mutua de Terrassa, Barcelona, Spain

[7] Fdn Caubet Cimero, Bunyola, Mallorca, Spain

来源：

REVISTA CLINICA ESPANOLA | 2011年 / 211卷 / 09期

关键词：

COPD; Osteoporosis; Fracture; BONE-MINERAL DENSITY; VERTEBRAL FRACTURES; COPD; PREVALENCE; MORTALITY; THERAPY; HEALTH; ECCO;

D O I：

10.1016/j.rce.2011.04.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: Osteoporosis is a frequent comorbidity in patients with chronic obstructive pulmonary disease (COPD). We have studied the risk of major osteoporotic fracture and hip fracture in patients with COPD. Patients and methods: A multicenter cross-sectional study was performed in Spain in 26 hospitals of 16 regional communities. Patients diagnosed with COPD who required admission to the Internal Medicine Service due to exacerbation of their respiratory disease were enrolled. COPD was confirmed by post-bronchodilator spirometry in stable state: maximum expiratory volume in the first second (FEV1) <80% of the theoretical value and quotient FEV1 /FVC <0.70 and percent predicted after the administration of a bronchodilator. Dyspnea was evaluated with the modified Medical Research Council (mMRC) dyspnea scale. The principal variable was the likelihood of fracture evaluated with the FRAX (R) tool for the Spanish population. Results: Three hundred and ninety two patients, 347 (88%) men, with a mean (SD) age of 73.7 (8.9) years and a mean FEV1 of 1.23 liters (43.3% of predicted) were enrolled. Only 37 patients (9.4%), 27 men and 10 women had been diagnosed previously of osteoporosis. Overall, 1.8% (95% CI: 0.9-3.6) had a 10-year probability of major osteoporotic fracture >= 20% and 49.7% (95% Cl: 44.8-54.7) had a probability of hip fracture >= 3%. No relationship was observed between the probability of fracture and GOLD stage or mMRC dyspnea scale. Conclusions: The diagnosis of osteoporosis is uncommon in our COPD patients. However, half of them have a high probability of a hip fracture in the next 10 years. (C) 2011 Elsevier Espana, S.L. All rights reserved.

引用

页码：443 / 449

页数：7

共 34 条

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