Specific prebiotics in a formula for infants with Phenylketonuria

被引:27
作者
MacDonald, Anita [1 ]
Cochrane, Barbara [2 ]
Wopereis, Harm [3 ]
Loveridge, Nik [4 ]
机构
[1] Birmingham Childrens Hosp, Birmingham B4 6NH, W Midlands, England
[2] Royal Hosp Sick Children, Glasgow G3 8SJ, Lanark, Scotland
[3] Ctr Specialised Nutr, Wageningen, Netherlands
[4] Nutricia Adv Med Nutr, Liverpool, Merseyside, England
关键词
Infant nutrition disorders; Infant formula; Nutrition therapy; Phenylketonuria; Prebiotics; Fibers; CHAIN FRUCTO-OLIGOSACCHARIDES; HUMAN COLONIC MICROBIOTA; GALACTO-OLIGOSACCHARIDES; HUMAN-MILK; DIETARY MODULATION; BIFIDOBACTERIUM; TIME; MICROFLORA; INFECTION; FECES;
D O I
10.1016/j.ymgme.2011.09.015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: This exploratory study investigated the influence of adding a patented, specific mixture of prebiotic oligosaccharides (scGOS/IcFOS [9:1 ratio], Danone Research) to a protein substitute suitable for infants with Phenylketonuria (PKU); PKU Anamix Infant (Nutricia). Design: This was an 8-week open-label, single-arm, pilot intervention study in 9 infants (8-week median age) diagnosed with PKU. On study entry, infants were prescribed PKU Anamix Infant to replace an infant phenylalanine-free protein substitute without prebiotics (IPS). Blood phenylalanine concentrations were monitored and stool samples analyzed for pH/bacterial groups. Results: PKU Anamix infant was well tolerated and accepted with no adverse events reported. Overall, plasma phenylalanine and tyrosine concentrations were maintained within target ranges throughout the study (120-360 mu nol/l phenylalanine, 30-100 mu mol/l tyrosine). All infants exhibited microbiota dominated by bifidobacteria (median 58.97% at Week 8), although no statistically significant change from baseline was observed at study endpoint. No infants showed abnormally high levels of Clostridium histolyticum/lituseburense or potentially pathogenic enterobacteriaceae at any point during the study. A significant reduction in median stool pH versus baseline was observed at Week 4 (pH reduced from 6.79 to 5.83), but this significance was not present at Week 8 (pH = 6.61). Conclusions: PKU Anamix Infant maintains phenylalanine control in line with established IPS without prebiotics and maintains levels of bifidobacteria and lowers stool pH. In exclusively breast-fed infants the latter two factors have been associated with a reduced risk of infection and may be of particular importance in infants with PKU. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:S55 / S59
页数:5
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