Left atrial function and scar after catheter ablation of atrial fibrillation

被引：142

作者：

Wylie, John V., Jr. ^{[1
]}

Peters, Dana C. ^{[1
]}

Essebag, Vidal ^{[1
]}

Manning, Warren J. ^{[1
,2
]}

Josephson, Mark E. ^{[1
]}

Hauser, Thomas H. ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med,Cardiovasc Div, Boston, MA 02215 USA

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Radiol, Boston, MA 02215 USA

来源：

HEART RHYTHM | 2008年 / 5卷 / 05期

基金：

加拿大健康研究院;

关键词：

catheter ablation; arrhythmia; atrium; atrial fibrillation; magnetic resonance imaging;

D O I：

10.1016/j.hrthm.2008.02.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Catheter ablation of atrial fibrillation (AF) involves extensive radiofrequency ablation (RFA) of the left atrium (LA) around the pulmonary veins. The effect of this therapy on LA function is not fully characterized. OBJECTIVE The purpose of this study was to determine whether catheter ablation of AF is associated with a change in LA function. METHODS LA and right atrial (RA) systolic function was assessed in 33 consecutive patients with paroxysmal or persistent AF referred for ablation using cardiovascular magnetic resonance (CMR) imaging. Steady-state free precession ECG cine CMR imaging was performed before and after (mean 48 days) AF ablation. ALL patients underwent circumferential pulmonary vein isolation using an 8-mm tip RFA catheter. High spatial resolution Late gadolinium enhancement CMR images of LA scar were obtained in 16 patients. RESULTS Maximum LA volume decreased by 15% (P <.001), and LA ejection fraction decreased by 14% (P <.001) after AF ablation. Maximum RA volume decreased by 13% (P =.018), but RA ejection fraction increased by 5% (P =.008). Mean LA scar volume was 8.1 +/- 3.7 mL. A Linear correlation was observed between change in LA ejection fraction and scar volume (r = -0.75, P <.001). CONCLUSION Catheter ablation of AF is associated with decreased LA size and reduced atrial systolic function. This change strongly correlates with the volume of LA scar. This finding may have implications for postprocedural thromboembolic risk and for procedures involving more extensive RFA.

引用

页码：656 / 662

页数：7

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