Capsaicin: From Plants to a Cancer-Suppressing Agent

被引：181

作者：

Chapa-Oliver, Angela M. ^{[1
]}

Mejia-Teniente, Laura ^{[2
]}

机构：

[1] Univ Celaya, Dept Nutr, Carretera Panamer Km 269 Col Rancho Pinto, Celaya 38080, Mexico

[2] Univ Guanajuato, CA Biotecnol Sustentabilidad & Ingn, Programa Ingn Biotecnol, Dept Ingn Agroind,Div Ciencias Salud & Ingn, Campus Celaya Salvatierra, Celaya 38060, Gto, Mexico

来源：

MOLECULES | 2016年 / 21卷 / 08期

关键词：

capsaicin; elicitors; stress; cancer; apoptosis; cell death; CELL-CYCLE ARREST; CAPSICUM-CHINENSE JACQ; PROSTATE PC-3 CELLS; INDUCED APOPTOSIS; PROVIDES INSIGHTS; OXIDATIVE STRESS; GENE-EXPRESSION; MELANOMA-CELLS; TRP CHANNELS; ANNUUM L;

D O I：

10.3390/molecules21080931

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Capsaicinoids are plant secondary metabolites, capsaicin being the principal responsible for the pungency of chili peppers. It is biosynthesized through two pathways involved in phenylpropanoid and fatty acid metabolism. Plant capsaicin concentration is mainly affected by genetic, environmental and crop management factors. However, its synthesis can be enhanced by the use of elicitors. Capsaicin is employed as food additive and in pharmaceutical applications. Additionally, it has been found that capsaicin can act as a cancer preventive agent and shows wide applications against various types of cancer. This review is an approach in contextualizing the use of controlled stress on the plant to increase the content of capsaicin, highlighting its synthesis and its potential use as anticancer agent.

引用

页数：14

共 92 条

[1] Molecular targets of dietary agents for prevention and therapy of cancer [J].

Aggarwal, BB ;

Shishodia, S .

BIOCHEMICAL PHARMACOLOGY, 2006, 71 (10) :1397-1421

[2] GENETIC DIVERSITY AND STRUCTURE IN SEMIWILD AND DOMESTICATED CHILES (CAPSICUM ANNUUM; SOLANACEAE) FROM MEXICO [J].

Aguilar-Melendez, Araceli ;

Morrell, Peter L. ;

Roose, Mikeal L. ;

Kim, Seung-Chul .

AMERICAN JOURNAL OF BOTANY, 2009, 96 (06) :1190-1202

[3]

Al-Snafi AE, 2015, J. Pharma. Biol., V5, P124

[4]

[Anonymous], 2002, Opinion of the Scientific Committee on Food on the Risk to Human Health of Polycyclic Aromatic Hydrocarbons - Occurrence in Food

[5]

Arora R., 2011, International Journal of Pharmaceutical Sciences and Drug Research, V3, P280

[6] Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: How vanilloids cause non-vanilloid receptor mediated cell death [J].

Athanasiou, Andriani ;

Smith, Paul A. ;

Vakilpour, Sara ;

Kumaran, Nethia M. ;

Turner, Amy E. ;

Bagiokou, Dimitra ;

Layfield, Robert ;

Ray, David E. ;

Westwell, Andrew D. ;

Alexander, Stephen P. H. ;

Kendall, David A. ;

Lobo, Dileep N. ;

Watson, Susan A. ;

Lophatanon, Artitaya ;

Muir, Kenneth A. ;

Guo, De-an ;

Bates, Timothy E. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 354 (01) :50-55

[7] Immunotherapy of tumors with neuroimmune ligand capsaicin [J].

Beltran, Jacqueline ;

Ghosh, Amiya K. ;

Basu, Sreyashi .

JOURNAL OF IMMUNOLOGY, 2007, 178 (05) :3260-3264

[8] Mitochondria-Judges and Executioners of Cell Death Sentences [J].

Bhola, Patrick D. ;

Letai, Anthony .

MOLECULAR CELL, 2016, 61 (05) :695-704

[9] Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation (Publication with Expression of Concern. See vol. 24, pg. 4346, 2018) [J].

Bhutani, Manisha ;

Pathak, Ashutosh K. ;

Nair, Asha S. ;

Kunnumakkara, Ajaikumar B. ;

Guha, Sushovan ;

Sethi, Gautam ;

Aggarwal, Bharat B. .

CLINICAL CANCER RESEARCH, 2007, 13 (10) :3024-3032

[10] A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin [J].

Bley, Keith ;

Boorman, Gary ;

Mohammad, Bashir ;

McKenzie, Donald ;

Babbar, Sunita .

TOXICOLOGIC PATHOLOGY, 2012, 40 (06) :847-873

← 1 2 3 4 5 6 7 8 9 10 →