Catalytic asymmetric synthesis of pyrrolidine derivatives bearing heteroatom-substituted quaternary stereocenters

被引：20

作者：

Wang, Zhi-Peng ^{[1
]}

Wu, Qi ^{[1
]}

Jiang, Jia ^{[1
]}

Li, Zi-Rui ^{[1
]}

Peng, Xiao-Jiao ^{[1
]}

Shao, Pan-Lin ^{[1
]}

He, Yun ^{[1
]}

机构：

[1] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, 55 Daxuecheng South Rd, Chongqing 401331, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 01期

基金：

中国国家自然科学基金;

关键词：

FORMAL 3+2 CYCLOADDITION; N-HETEROCYCLIC CARBENES; AZOMETHINE YLIDES; 1,3-DIPOLAR CYCLOADDITION; ENANTIOSELECTIVE SYNTHESIS; ALDOL REACTIONS; STEREOSELECTIVE-SYNTHESIS; METHYL ISOCYANOACETATE; ALPHA-ISOCYANOACETATES; MICHAEL ADDITION;

D O I：

10.1039/c7qo00692f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective [3 + 2] cycloaddition of heteroatom-substituted alkenes with alpha-substituted isocyanoacetates has been developed. The resulting cycloadducts could be further transformed to access a number of structurally diverse and biologically important pyrrolidine derivatives which bear sulfur-or oxygen-substituted quaternary stereocenters. Excellent reactivity and enantioselectivity were obtained for a broad range of substrates.

引用

页码：36 / 40

页数：5

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