Inhibitor of Differentiation 1 (Id1) in Cancer and Cancer Therapy

被引:77
作者
Zhao, Zhengxiao [1 ]
Bo, Zhiyuan [2 ]
Gong, Weiyi [3 ]
Guo, Yong [1 ]
机构
[1] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Oncol, Hangzhou 310006, Zhejiang, Peoples R China
[2] Shanghai Eastern Hepatobiliary Surg Hosp, Dept Biliary Tract Surg 2, Shanghai 200438, Peoples R China
[3] Fudan Univ, Huashan Hosp, Dept Integrat Med, 12 Middle Urumqi Rd, Shanghai 200040, Peoples R China
基金
中国国家自然科学基金;
关键词
Id1; Cancer; Signaling pathway; Angiogenesis; Resistance; Target; LOOP-HELIX PROTEIN; CELL LUNG-CANCER; SMALL INTERFERING RNA; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; PROGNOSTIC-FACTOR; GENE-EXPRESSION; DNA-BINDING; HUMAN PAPILLOMAVIRUSES; REGULATES GROWTH;
D O I
10.7150/ijms.42805
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The inhibitor of DNA binding (Id) proteins are regulators of cell cycle and cell differentiation. Of all Id family proteins, Id1 is mostly linked to tumorigenesis, cellular senescence as well as cell proliferation and survival. Id1 is a stem cell-like gene more than a classical oncogene. Id1 is overexpressed in numerous types of cancers and exerts its promotion effect to these tumors through different pathways. Briefly, Id1 was found significantly correlated with EMT-related proteins, K-Ras signaling, EGFR signaling, BMP signaling, PI3K/Akt signaling, WNT and SHH signaling, c-Myc signaling, STAT3 signaling, RK1/2 MAPK/Egr1 pathway and TGF-beta pathway, etc. Id1 has potent effect on facilitating tumorous angiogenesis and metastasis. Moreover, high expression of Id1 plays a facilitating role in the development of drug resistance, including chemoresistance, radiation resistance and resistance to drugs targeting angiogenesis. However, controversial results were also obtained. Overall, Id1 represent a promising target of anti-tumor therapeutics based on its potent promotion effect to cancer. Numerous drugs were found exerting their anti-tumor function through Id1-related signaling pathways, such as fucoidan, berberine, tetramethylpyrazine, crizotinib, cannabidiol and vinblastine.
引用
收藏
页码:995 / 1005
页数:11
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