Statin therapy and the acute inflammatory response after coronary artery bypass grafting

被引：49

作者：

Brull, DJ

Sanders, J

Rumley, A

Lowe, GDO

Humphries, SE

Montgomery, HE

机构：

[1] UCL Royal Free & UCL Med Sch, Dept Med, British Heart Fdn Labs, Ctr Cardiovasc Genet, London WC1E 6JJ, England

[2] Glasgow Royal Infirm, Dept Med, Glasgow G4 0SF, Lanark, Scotland

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 88卷 / 04期

关键词：

D O I：

10.1016/S0002-9149(01)01696-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Preoperative statin therapy has been shown to improve cardiovascular outcome after coronary artery bypass grafting; however, the clinical gain achieved is in excess of the reduction in lipids. We demonstrate that statin therapy exerts a direct anti-inflammatory effect mediated through reduced interleukin-6 production.

引用

页码：431 / +

页数：4

共 12 条

[1] EFFECT OF PRAVASTATIN ON PROGRESSION AND REGRESSION OF CORONARY ATHEROSCLEROSIS AND VESSEL WALL CHANGES IN CAROTID AND FEMORAL ARTERIES - A REPORT FROM THE REGRESSION GROWTH EVALUATION STATIN STUDY [J].

DEGROOT, E ;

JUKEMA, JW ;

VANBOVEN, AJ ;

REIBER, JHC ;

ZWINDERMAN, AH ;

LIE, KI ;

ACKERSTAFF, RA ;

BRUSCHKE, AVG .

AMERICAN JOURNAL OF CARDIOLOGY, 1995, 76 (09) :C40-C46

[2] Effect of preoperative statin therapy and cardiac outcomes after coronary artery bypass grafting [J].

Dotani, MI ;

Elnicki, DM ;

Jain, AC ;

Gibson, CM .

AMERICAN JOURNAL OF CARDIOLOGY, 2000, 86 (10) :1128-+

[3]

Foody JM, 2000, CIRCULATION, V102, P90

[4] Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect -: Reduction of MRNA levels for interleukin-1β, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor α (PPARα) in primary endothelial cells [J].

Inoue, I ;

Goto, S ;

Mizotani, K ;

Awata, T ;

Mastunaga, T ;

Kawai, S ;

Nakajima, T ;

Hokari, S ;

Komoda, T ;

Katayama, S .

LIFE SCIENCES, 2000, 67 (08) :863-876

[5] Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability [J].

Koh, KK .

CARDIOVASCULAR RESEARCH, 2000, 47 (04) :648-657

[6] Low-density lipoprotein-induced expression of interleukin-6, a marker of human mesangial cell inflammation: Effects of oxidation and modulation by lovastatin [J].

Massy, ZA ;

Kim, Y ;

Guijarro, C ;

Kasiske, BL ;

Keane, WF ;

O'Donnell, MP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 267 (02) :536-540

[7]

OLIVER MF, 1994, LANCET, V344, P633

[8]

PEDERSEN TR, 1994, LANCET, V344, P1383

[9] PRAVASTATIN LIMITATION OF ATHEROSCLEROSIS IN THE CORONARY-ARTERIES (PLAC-I) - REDUCTION IN ATHEROSCLEROSIS PROGRESSION AND CLINICAL EVENTS [J].

PITT, B ;

MANCINI, GBJ ;

ELLIS, SG ;

ROSMAN, HS ;

PARK, JS ;

MCGOVERN, ME .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1995, 26 (05) :1133-1139

[10] Mother/daughter discourse in a Holocaust oral history: "Because then you admit that you're guilty" [J].

Schiffrin, D .

NARRATIVE INQUIRY, 2000, 10 (01) :1-44

← 1 2 →