Synthesis of oligosaccharides of motifs D and E of arabinogalactan present in Mycobacterium tuberculosis

被引：32

作者：

Gurjar, MK ^{[1
]}

Reddy, LK ^{[1
]}

Hotha, S ^{[1
]}

机构：

[1] Natl Chem Lab, Pune 411008, Maharashtra, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 13期

关键词：

D O I：

10.1021/jo010180a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses of the ethyl glycosides of 5-O-(beta -D-galactofuranosyl)-beta -D-galactofuranose and 5-O-(alpha -D-arabinofuranosyl)-6-O-(beta -D-galactofuranosyl)-beta -D-galactofuranose present in motifs D and E of Mycobacterium tuberculosis arabinogalactan, respectively, have been presented. The pentenyl-mediated O-glycosylation reaction was utilized to obtain the disaccharide of motif D. The first coupling reaction to prepare the inner disaccharide portion of motif E was accomplished by trichloroacetamidate method while the installation of the terminal sugar by pentenyl glycosylation approach was successful.

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页码：4657 / 4660

页数：4

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