Genetics of obsessive-compulsive disorder

被引：24

作者：

Purty, Abhishek ^{[1
]}

Nestadt, Gerald ^{[2
]}

Samuels, Jack F. ^{[2
]}

Viswanath, Biju ^{[1
]}

机构：

[1] Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Bengaluru 560029, Karnataka, India

[2] Johns Hopkins Univ, Dept Behav Sci & Psychiat, Baltimore, MD USA

来源：

INDIAN JOURNAL OF PSYCHIATRY | 2019年 / 61卷 / 07期

关键词：

Candidate gene study; family study; genetics; genome-wide association study; linkage study; obsessive-compulsive disorder; twin study; GENOME-WIDE ASSOCIATION; ENVIRONMENTAL RISK-FACTORS; FAMILY-BASED ASSOCIATION; TRANSPORTER GENE; DIMENSIONAL REPRESENTATIONS; CLINICAL CHARACTERISTICS; SEROTONIN TRANSPORTER; SLC1A1; GENE; OCD; POPULATION;

D O I：

10.4103/psychiatry.IndianJPsychiatry_518_18

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Obsessive-compulsive disorder (OCD) has been seen to run in families and genetics help to understand its heritability. In this review, we summarize older studies which focused on establishing the familial nature of OCD, including its various dimensions of symptoms, and we focus on recent findings from studies using both the candidate gene approach and genome-wide association study (GWAS) approach. The family studies and twin studies establish the heritability of OCD. Candidate gene approaches have implicated genes in the serotonergic, glutamatergic, and dopaminergic pathways. GWAS has not produced significant results possibly due to the small sample size. Newer techniques such as gene expression studies in brain tissue, stem cell technology, and epigenetic studies may shed more light on the complex genetic basis of OCD.

引用

页码：S37 / S42

页数：6

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