Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

被引：13

作者：

Dhanjal, Daljeet Singh ^{[1
]}

Sharma, Parvarish ^{[2
]}

Mehta, Meenu ^{[3
]}

Tambuwala, Murtaza M. ^{[4
]}

Prasher, Parteek ^{[5
]}

Paudel, Keshav R. ^{[6
,7
]}

Liu, Gang ^{[6
,7
]}

Shukla, Shakti D.

Hansbro, Philip M. ^{[6
,7
]}

Chellappan, Dinesh Kumar ^{[8
]}

Dua, Kamal ^{[3
]}

Satija, Saurabh ^{[2
]}

机构：

[1] Lovely Profess Univ, Sch Bioengn & Biosci, Phagwara 144411, Punjab, India

[2] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India

[3] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia

[4] Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland

[5] Univ Petr & Energy Studies, Dept Chem, Dehra Dun 248007, Uttarakhand, India

[6] Centenary Inst, Ctr Inflammat, Sydney, NSW, Australia

[7] Univ Technol Sydney, Sch Life Sci, Fac Sci, Sydney, NSW, Australia

[8] Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur 57000, Malaysia

来源：

FUTURE MEDICINAL CHEMISTRY | 2022年 / 14卷 / 04期

基金：

英国医学研究理事会;

关键词：

COPD; NDDS; remodeling; respiratory disorders; OBSTRUCTIVE PULMONARY-DISEASE; OVERCOMING BIOLOGICAL BARRIERS; SOLID LIPID NANOPARTICLES; DRUG-DELIVERY; INHALER TECHNIQUE; CARBON NANOTUBES; MURINE MODEL; IN-VITRO; ASTHMA; CHALLENGES;

D O I：

10.4155/fmc-2021-0081

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chronic respiratory disorders (CRDs) affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.

引用

页码：271 / 288

页数：18

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