A protecting group-free synthesis of the antineoplastic agent combretastatin A4

被引：3

作者：

Guo, Xiaotao ^{[1
]}

Zhang, Dan ^{[1
]}

Yu, Zhifang ^{[1
]}

Liu, Tianzhen ^{[1
]}

Li, Dachang ^{[1
]}

Li, Chunbao ^{[1
]}

机构：

[1] Tianjin Univ, Coll Sci, Dept Chem, Tianjin 300072, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2011年 / 04期

关键词：

antineoplastic agent; combretastatin A4; synthesis; Wittig reaction; irradiation; A-4; COLCHICINE; TUBULIN; ANALOGS;

D O I：

10.3184/174751911X13024592068428

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of combretastatin A4 (CA4) from commercially available inexpensive materials has been achieved via the Wittig reaction followed by irradiation of the (Z)/(E)-CA4 reaction mixture with sunlight. The method resulted in (Z)-CA4 in high yield. This method does not require protection of the phenolic hydroxy group. The synthesis is operationally simple and cost-efficient.

引用

页码：229 / 230

页数：2

共 34 条

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