Synthesis of CF3-containing α-alkynyl-α-aminophosphonates by Sonogashira cross-coupling reaction

被引：13

作者：

Zotova, Maria A. ^{[1
]}

Vasilyeva, Tamara P. ^{[1
]}

Peregudov, Alexander S. ^{[1
]}

Osipov, Sergey N. ^{[1
]}

机构：

[1] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2012年 / 135卷

关键词：

Aminophosphonates; Alkynes; Cross-coupling; Hydrogenation; ACID-DERIVATIVES; AMINO-ACIDS; INHIBITORS; PHOSPHONOPEPTIDES;

D O I：

10.1016/j.jfluchem.2011.07.028

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient route to new alpha-CF3-alpha-aminophosphonic acid derivatives bearing an arylalkynyl moiety at the alpha-carbon atom has been developed. The method is based on palladium-catalyzed cross-coupling of the corresponding alpha-propargyl (ethynyl) alpha-aminophosphonates with aryl iodides to afford the aminophosphonic acid derivatives with an internal triple bond that is suitable for further modifications. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：33 / 37

页数：5

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